INT345370

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.29
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
endothelial cell 2
Vegfa (Mus musculus)
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 82.68 Quite High
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 230 96.96 Very High Very High Very High
Stomach Cancer 2 76.24 Quite High
Prostate Cancer 2 75.16 Quite High
Metastasis 124 66.88 Quite High
Targeted Disruption 6 47.44 Quite Low
Skin Cancer 4 34.48 Quite Low
Carcinoma 24 5.00 Very Low Very Low Very Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Breast Cancer 12 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
VEGF Binding (binding) of receptor in endothelial cell
1) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.14 Pain Relevance 0.04
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
VEGF Binding (binding) of receptor in endothelial cell
2) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.14 Pain Relevance 0.04

General Comments

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