INT345374

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Flt4) extracellular space (VEGFA) growth (VEGFA)
extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) plasma membrane (Flt4)
Anatomy Link Frequency
endothelial cells 2
VEGFA (Homo sapiens)
Flt4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 36.56 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 230 94.88 High High
Metastasis 124 93.88 High High
Breast Cancer 12 83.84 Quite High
Lymphatic Metastasis 4 75.76 Quite High
Immunotherapy Of Cancer 2 63.16 Quite High
Recurrence 2 53.76 Quite High
Advanced Or Metastatic Breast Cancer 4 51.48 Quite High
Malignant Neoplastic Disease 6 51.00 Quite High
Hyperplasia 2 40.32 Quite Low
Injury 2 27.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, VEGFR-3, the VEGF-C receptor, is predominantly expressed on lymphatic endothelial cells [29], and VEGF-C-dependent activation of VEGFR-3 stimulates the growth of lymphatic endothelial cells and lymphatics [30].
VEGF Positive_regulation (activation) of VEGFR-3 in endothelial cells
1) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.75 Pain Relevance 0
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
VEGF Positive_regulation (activates) of VEGFR-3 in endothelial cells
2) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.20 Pain Relevance 0

General Comments

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