INT345421

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif2ak2) nucleus (Eif2ak2) intracellular (Eif2ak2)
translation (Eif2ak2) kinase activity (Eif2ak2)
IFNA1 (Homo sapiens)
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 24 94.24 High High
Inflammation 51 89.32 High High
cytokine 77 75.16 Quite High
dopaminergic neurodegeneration 1 72.72 Quite High
Dopamine 61 63.56 Quite High
chemokine 4 35.80 Quite Low
midbrain 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 8 97.92 Very High Very High Very High
Stress 4 92.72 High High
INFLAMMATION 69 89.32 High High
Hepatitis C Virus Infection 146 85.84 High High
Viremia 1 85.52 High High
Neurodegenerative Disease 17 78.28 Quite High
Infection 25 74.88 Quite High
Renal Insufficiency 3 72.72 Quite High
Parkinson's Disease 20 60.32 Quite High
Disease 108 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, ribavirin may act synergistically with IFN by upregulating the activity of double-stranded RNA-activated protein kinase and enhances the action of interferon-alfa against hepatitis C virus [17].
IFN Positive_regulation (upregulating) of RNA-activated protein kinase associated with hepatitis
1) Confidence 0.03 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 0.56 Pain Relevance 0
induces microglial expression of iNOS and several key subunits of NADPH oxidase [126], as well as the IFN-inducible double-stranded RNA-activated kinase, PKR [127].
IFN Positive_regulation (inducible) of PKR
2) Confidence 0.01 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.69 Pain Relevance 0.30

General Comments

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