INT34544

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 43
Total Number 45
Disease Relevance 5.30
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 5
olfactory bulb 3
hippocampus 2
cerebellum 2
astrocyte 2
L1cam (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 12 100.00 Very High Very High Very High
Central nervous system 156 99.94 Very High Very High Very High
Dopamine 26 99.80 Very High Very High Very High
fifth nerve 156 99.76 Very High Very High Very High
Dermatone 2 99.76 Very High Very High Very High
Hippocampus 234 99.68 Very High Very High Very High
Spinal cord 173 99.20 Very High Very High Very High
unmyelinated 4 98.80 Very High Very High Very High
cytokine 34 98.28 Very High Very High Very High
cerebral cortex 182 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 103 100.00 Very High Very High Very High
Injury 8 99.92 Very High Very High Very High
Anxiety Disorder 107 99.56 Very High Very High Very High
Urological Neuroanatomy 182 95.68 Very High Very High Very High
Infection 26 94.08 High High
Congenital Anomalies 3 93.88 High High
Fasciculation 29 92.40 High High
Apoptosis 78 87.12 High High
Intellectual Impairment 1 86.56 High High
Pain 8 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some previous studies pointed that L1 is expressed in adults in the olfactory bulb [16], optic nerve [17], hippocampus [8,10,11] and cerebellum [18].
Gene_expression (expressed) of L1 in olfactory bulb associated with hippocampus
1) Confidence 0.77 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.07 Pain Relevance 0.38
More studies are needed to examine such effects; i.e. double immunoelectron microscopic analysis to detect L1 and dopamine-related molecules, and a biochemical approach to detect L1 in the dopaminergic signalling system.
Gene_expression (detect) of L1 associated with dopamine
2) Confidence 0.77 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.15
We confirmed these findings except for those in the optic nerve and further identified novel sites of expression of L1, which had not been described before.
Gene_expression (expression) of L1 in optic nerve
3) Confidence 0.77 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.09 Pain Relevance 0.42
Therefore, the result did not support the notion that L1 is present in the axons of the thick bundles, though a more detailed study using an electron microscope is necessary (see Fig. 2a,2b,2c,2d).
Gene_expression (present) of L1
4) Confidence 0.77 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.17
During the third postnatal week (e.g., P16), whereas NF186 was highly restricted to AIS-soma of Purkinje cells [13], L1 was abundantly expressed in parallel fibers and other unmyelinated and premyelinated axons (Figure S2D and S2G).
Gene_expression (expressed) of L1 in parallel fibers associated with unmyelinated
5) Confidence 0.74 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.09
Like other members of the L1CAM [20], CHL1 is expressed in both neurons and glia [31,53].
Gene_expression (expressed) of L1CAM in neurons
6) Confidence 0.74 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.08
We therefore systematically examined the expression pattern of every L1CAM during the postnatal development of the cerebellar cortex.
Spec (examined) Gene_expression (expression) of L1CAM in cerebellar cortex
7) Confidence 0.74 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.08
To express L1, High5 cells were infected with recombinant baculovirus.
Gene_expression (express) of L1
8) Confidence 0.67 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.09 Pain Relevance 0
g) was absorbed with the L1-expressing cell membrane fraction (2 × 107 cells) resuspended in 1 ml of 0.1 M PBS, 5 % bovine serum albumin, and 100 mM PMSF at 4°C for 48 h.
Gene_expression (absorbed) of L1
9) Confidence 0.66 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.08 Pain Relevance 0
This result strongly suggested that L1 in the stria terminalis is not present inside of axons but instead in the myelin, oligodendroglia, or astroglia.
Neg (not) Gene_expression (present) of L1 in oligodendroglia
10) Confidence 0.66 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.18
The globus pallidus had the highest density of L1 immunoreactive fibres (Fig. 5i,5j).
Gene_expression (5i,5j) of L1 in globus pallidus
11) Confidence 0.66 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.03
Three kinds of L1 Immunoreactive structures observed by light microscope
Gene_expression (structures) of L1
12) Confidence 0.66 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.03
The third kind was somatic staining of L1 and this was very rare.
Gene_expression (staining) of L1
13) Confidence 0.66 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.07
The importance of L1 expression in the matured brain is suggested by physiological and behavioral studies showing that L1 is related to hippocampal plasticity and fear conditioning.
Gene_expression (expression) of L1 in brain associated with anxiety disorder
14) Confidence 0.59 Published 2003 Journal BMC Neurosci Section Abstract Doc Link PMC155647 Disease Relevance 0.09 Pain Relevance 0
In the central nervous system (CNS), L1 is expressed in the developing olfactory bulb, cerebellum and spinal cord [2-9].
Gene_expression (expressed) of L1 in spinal cord associated with central nervous system and spinal cord
15) Confidence 0.59 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.15 Pain Relevance 0.27
Behavioral analysis has shown that contextual fear conditioning induced L1 expression in the hippocampus [13].
Gene_expression (expression) of L1 in hippocampus associated with anxiety disorder and hippocampus
16) Confidence 0.59 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.26 Pain Relevance 0.33
Disruption of the mouse L1 gene leads to malformations of the nervous system.
Gene_expression (Disruption) of L1 in nervous system
17) Confidence 0.58 Published 1997 Journal Nat. Genet. Section Title Doc Link 9354804 Disease Relevance 0.48 Pain Relevance 0.07
The L1 immunoreactive structure of the spinal nucleus of the trigeminal nerve was concentrated only in the marginal zone and this continued caudally to the substantia gelatinosa of the dorsal horn.
Gene_expression (structure) of L1 in dorsal horn associated with substantia gelatinosa, fifth nerve and dorsal horn
18) Confidence 0.58 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.10 Pain Relevance 0.70
It was found that there was no accumulation of L1 on the proximal side of the transected nerve (Fig. 2a,2a'), and no reduction of L1 on the distal side of the lesion (Fig. 2c,2c') or in the terminal field (data not shown).
Neg (no) Gene_expression (reduction) of L1 in proximal
19) Confidence 0.58 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.25
L1 immunoreactive structures in the forebrain
Gene_expression (structures) of L1 in forebrain
20) Confidence 0.58 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.28

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