INT34545

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 1.18
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dermatome 2
astrocyte 2
grey matter 1
cranial 1
lateral olfactory tract 1
L1cam (Mus musculus)
Pain Link Frequency Relevance Heat
Dermatone 4 99.68 Very High Very High Very High
intrathecal 8 98.04 Very High Very High Very High
anesthesia 14 97.18 Very High Very High Very High
substance P 48 97.08 Very High Very High Very High
analgesia 4 94.08 High High
Raphe 32 93.68 High High
Neuropeptide 16 92.60 High High
Glutamate 21 92.40 High High
fifth nerve 48 88.72 High High
Periaqueductal grey 48 87.56 High High
Disease Link Frequency Relevance Heat
Nociception 17 99.16 Very High Very High Very High
Anxiety Disorder 32 88.04 High High
Urological Neuroanatomy 56 87.56 High High
Cancer 7 62.48 Quite High
Metastasis 2 61.52 Quite High
Apoptosis 28 57.84 Quite High
Rheumatoid Arthritis 52 51.76 Quite High
Arthritis 4 39.36 Quite Low
Osteoarthritis 1 38.08 Quite Low
Body Weight 8 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there was no accumulation of L1 in transected nerve, and no reduction in the terminal field of the stria terminalis.
Neg (no) Positive_regulation (accumulation) of L1 in nerve
1) Confidence 0.60 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.06 Pain Relevance 0.19
It was found that there was no accumulation of L1 on the proximal side of the transected nerve (Fig. 2a,2a'), and no reduction of L1 on the distal side of the lesion (Fig. 2c,2c') or in the terminal field (data not shown).
Neg (no) Positive_regulation (accumulation) of L1 in proximal
2) Confidence 0.60 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.25
Pontine grey matter had a moderate accumulation of fine L1 immunoreactive granules (Figs. 3j,3k,7h).
Positive_regulation (accumulation) of L1 in grey matter
3) Confidence 0.60 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0.17 Pain Relevance 0.34
The accumulation of immunoreactive L1 was greatest in a non-neuronal element of the major fibre bundles, i.e. the lateral olfactory tract, olfactory and temporal limb of the anterior commissure, corpus callosum, stria terminalis, globus pallidus, fornix, mammillothalamic tract, solitary tract, and spinal tract of the trigeminal nerve.
Positive_regulation (accumulation) of L1 in lateral olfactory tract associated with fifth nerve
4) Confidence 0.40 Published 2003 Journal BMC Neurosci Section Abstract Doc Link PMC155647 Disease Relevance 0.15 Pain Relevance 0.13
The injured cholinergic neurons which are regenerating their axons upregulate L1, and downregulate it upon target innervations.
Positive_regulation (upregulate) of L1 in cholinergic neurons
5) Confidence 0.40 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.08
Immunoreactive L1 was widely but unevenly distributed from the olfactory bulb to the upper cervical cord.
Positive_regulation (distributed) of L1 in olfactory bulb
6) Confidence 0.40 Published 2003 Journal BMC Neurosci Section Abstract Doc Link PMC155647 Disease Relevance 0.14 Pain Relevance 0.09
The cingulate area had the next densest accumulation of L1 immunoreactive granules among the cortical areas.
Positive_regulation (accumulation) of L1
7) Confidence 0.40 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC155647 Disease Relevance 0 Pain Relevance 0.04
The effect of spinal anesthesia with 3.6 +/- 0.1 ml (mean +/- SEM) of 0.5% bupivacaine on early (less than 150 msec) somatosensory evoked potentials (SEPs) with electrical stimulation of the L1 and S1 dermatomes was examined in 12 patients.
Positive_regulation (stimulation) of L1 in dermatomes associated with anesthesia and dermatone
8) Confidence 0.23 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 3039873 Disease Relevance 0 Pain Relevance 0.39
Intrathecal bupivacaine significantly (P less than 0.05) decreased the amplitude of all SEP components after stimulation of the L1 dermatome and most components during stimulation of the S1 dermatome.
Positive_regulation (stimulation) of L1 in dermatome associated with intrathecal
9) Confidence 0.20 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 3039873 Disease Relevance 0 Pain Relevance 0.49
The accumulation of immunoreactive L1 was greatest in a non-neuronal element of the major fibre bundles, i.e. the lateral olfactory tract, olfactory and temporal limb of the anterior commissure, corpus callosum, stria terminalis, globus pallidus, fornix, mammillothalamic tract, solitary tract, and spinal tract of the trigeminal nerve.
Positive_regulation (accumulation) of L1 in olfactory associated with fifth nerve
10) Confidence 0.14 Published 2003 Journal BMC Neurosci Section Abstract Doc Link PMC155647 Disease Relevance 0.15 Pain Relevance 0.13
Furthermore, the average frequency of Ca2+ surges in active astrocytes was higher in L1 than L2/3.
Positive_regulation (higher) of L1 in astrocytes
11) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0.08 Pain Relevance 0
Furthermore, Ca2+ fluctuations of processes within an astrocyte were independent in L1 while those in L2/3 were synchronous.
Neg (independent) Positive_regulation (independent) of L1 in astrocyte
12) Confidence 0.06 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2424136 Disease Relevance 0 Pain Relevance 0.24
One potential interpretation of the layer differences of astrocytic calcium dynamics is that the preparation of cranial window had nociceptive effects on astrocytes in the superficial L1 which resulted in turning the astrocytes to be ‘reactive’, which is indicated by increased expression of glial fibrillary acidic protein (GFAP) [23].
Positive_regulation (indicated) of L1 in cranial associated with nociception
13) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0.10 Pain Relevance 0
Since it was shown that L1 is induced by DNA demethylation, a novel search for epigenetic modifications in RASF has been conducted.
Positive_regulation (induced) of L1
14) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.34 Pain Relevance 0.14

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