INT345486

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PMAIP1, CYC1) cytosol (PMAIP1) transport (CYC1)
small molecule metabolic process (CYC1) nucleus (PMAIP1) cytoplasm (CYC1)
PMAIP1 (Homo sapiens)
CYC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 25.00 Low Low
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 100.00 Very High Very High Very High
Skin Cancer 1 88.56 High High
Mantle-cell Lymphoma 1 87.52 High High
Stress 1 84.80 Quite High
Hypoxia 1 80.04 Quite High
Death 1 65.08 Quite High
Cancer 12 55.60 Quite High
Adhesions 2 44.32 Quite Low
Neuropathic Pain 15 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
NOXA Positive_regulation (causes) of Localization (release) of cytochrome c associated with apoptosis
1) Confidence 0.18 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.96 Pain Relevance 0

General Comments

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