INT345487

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIF1A, PMAIP1) cell differentiation (HIF1A) mitochondrion (PMAIP1)
cytoplasm (HIF1A) signal transducer activity (HIF1A) cytosol (PMAIP1)
HIF1A (Homo sapiens)
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 48.04 Quite Low
peripheral neuropathy 26 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Duloxetine 2 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 100.00 Very High Very High Very High
Stress 2 96.52 Very High Very High Very High
Death 2 88.12 High High
Apoptosis 22 78.12 Quite High
Adhesions 4 67.36 Quite High
Cancer 24 60.28 Quite High
Skin Cancer 2 42.96 Quite Low
Mantle-cell Lymphoma 2 41.92 Quite Low
Neuropathic Pain 30 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NOXA is also induced by p53 and other transcriptional factors such as hypoxia-inducible factor 1 (HIF-1) and E2F-1, consistent with its involvement in the response to many types of cellular stress.
HIF-1 Positive_regulation (induced) of NOXA associated with stress and hypoxia
1) Confidence 0.27 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.62 Pain Relevance 0
NOXA is also induced by p53 and other transcriptional factors such as hypoxia-inducible factor 1 (HIF-1) and E2F-1, consistent with its involvement in the response to many types of cellular stress.
hypoxia-inducible factor 1 Positive_regulation (induced) of NOXA associated with stress and hypoxia
2) Confidence 0.05 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.62 Pain Relevance 0

General Comments

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