INT345504

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 72.48 Quite High
dexamethasone 30 69.24 Quite High
peripheral neuropathy 39 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Duloxetine 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Gabapentin 3 5.00 Very Low Very Low Very Low
vincristine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 33 100.00 Very High Very High Very High
Cancer 36 93.48 High High
Stress 3 84.80 Quite High
Skin Cancer 3 82.24 Quite High
Mantle-cell Lymphoma 3 81.20 Quite High
Hypoxia 3 80.04 Quite High
Death 3 65.08 Quite High
Adhesions 6 44.32 Quite Low
Peripheral Arterial Disease 3 17.16 Low Low
Neuropathic Pain 45 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of NOXA and c-myc also provides a possible rationale for the encouraging clinical data noted thus far when histone deacetylase (HDAC) inhibitors are combined with bortezomib.
NOXA Binding (interaction) of
1) Confidence 0.15 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.63 Pain Relevance 0
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
NOXA Binding (interaction) of associated with apoptosis
2) Confidence 0.13 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.88 Pain Relevance 0
B, the interaction of the pro-apoptotic factor NOXA and the c-myc oncogene, and finally, the transcription factor x-box binding protein 1 (XBP-1) and the unfolded protein response.
NOXA Binding (interaction) of associated with apoptosis
3) Confidence 0.13 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.18 Pain Relevance 0.10

General Comments

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