INT34552

Context Info Confidence 0.50 First Reported 1987 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 9 Disease Relevance 5.06 Pain Relevance 1.75

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Anatomy Link Frequency brain 7 myocardial cells 2 spinal cords 2 Heart 1 Alox5 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 35 98.08 Central nervous system 70 95.28 Hippocampus 63 94.56 cINOD 4 93.20 ischemia 14 88.56 IPN 1 87.40 depression 14 86.64 aspirin 2 86.60 Hyperalgesia 1 85.88 Analgesic 1 74.52

Disease Link Frequency Relevance Heat Aging 273 99.84 INFLAMMATION 37 98.08 Brain Hemorrhage 7 89.04 Inflammatory Pain 1 87.40 Urological Neuroanatomy 35 86.92 Depression 14 86.64 Hyperalgesia 1 85.88 Cv Unclassified Under Development 7 83.20 Disease 7 81.76 Neurodegenerative Disease 7 78.88

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Furthermore, in the heart, that is, myocardial cells, drugs such as statins and thiazolidinediones trigger anti-inflammatory processes and increase the production of anti-inflammatory lipoxins depending on 5-LOX, particularly the status of 5-LOX phosphorylation [15, 23]. 5-LOX gene expression is regulated by epigenetic mechanisms including modifications of DNA methylation [1, 24–26].

Regulation (regulated) of Gene_expression (expression) of 5-LOX in myocardial cells associated with inflammation

1) Confidence 0.50 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.57 Pain Relevance 0.28

Thus, regulation of the brain expression of 5-LOX participates in mechanisms of neuroprotection [8].

Regulation (regulation) of Gene_expression (expression) of 5-LOX in brain

2) Confidence 0.50 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.88 Pain Relevance 0.45

The reason for these discrepancies is not apparent, but considering the putative epigenetic regulation of 5-LOX expression, it is likely that individual life experiences of various colonies of old rodents could result in a colony-specific aging-modified epigenetic regulation of 5-LOX expression.

Regulation (regulation) of Gene_expression (expression) of 5-LOX associated with aging

3) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.78 Pain Relevance 0.13

Regardless of the observed regional differences, all previous studies [14, 17, 37] and our present results are consistent as to the direction (i.e., increase) of aging-associated changes in brain 5-LOX expression.

Regulation (changes) of Gene_expression (expression) of 5-LOX in brain associated with aging

4) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.80 Pain Relevance 0.11

5-Lipoxygenase DNA Methylation and mRNA Content in the Brain and Heart of Young and Old Mice The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation.

Regulation (affected) of in Heart Gene_expression (expression) of 5-LOX in Brain associated with aging

5) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Title Doc Link PMC2801004 Disease Relevance 0.38 Pain Relevance 0

The reason for these discrepancies is not apparent, but considering the putative epigenetic regulation of 5-LOX expression, it is likely that individual life experiences of various colonies of old rodents could result in a colony-specific aging-modified epigenetic regulation of 5-LOX expression.

Regulation (regulation) of Gene_expression (expression) of 5-LOX associated with aging

6) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.84 Pain Relevance 0.12

Although no changes in 5-LO or 12-LO expression were seen by Western blot analysis or by immunohistochemistry in spinal cords of dipyrone-treated mice, the activation of both enzymes was verified by determining LO-products.

Neg (no) Regulation (changes) of Gene_expression (expression) of 5-LO in spinal cords

7) Confidence 0.18 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.25 Pain Relevance 0.28

[The effect of benzydamine on the generation and interaction of reactive oxygen species and cyclo- and lipoxygenase].

Regulation (effect) of Gene_expression (generation) of lipoxygenase

8) Confidence 0.13 Published 1987 Journal Arzneimittelforschung Section Title Doc Link 3040020 Disease Relevance 0.19 Pain Relevance 0.38

5-Lipoxygenase DNA Methylation and mRNA Content in the Brain and Heart of Young and Old Mice The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation.

Regulation (affected) of Gene_expression (expression) of 5-LOX in Brain associated with aging

9) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Title Doc Link PMC2801004 Disease Relevance 0.38 Pain Relevance 0

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