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Context Info
Confidence 0.10
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.65
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 7 99.30 Very High Very High Very High
cINOD 7 93.20 High High
aspirin 4 86.60 High High
Inflammation 24 77.76 Quite High
Bioavailability 2 73.52 Quite High
Pain 4 25.00 Low Low
Potency 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 96.12 Very High Very High Very High
Atherosclerosis 53 90.84 High High
Atherosclerotic Plaque 3 75.68 Quite High
Coronary Artery Disease 6 28.92 Quite Low
Disorder Of Lipid Metabolism 12 5.32 Low Low
Hypertension 14 5.00 Very Low Very Low Very Low
Cardiovascular Disease 11 5.00 Very Low Very Low Very Low
Stroke 9 5.00 Very Low Very Low Very Low
Coronary Heart Disease 8 5.00 Very Low Very Low Very Low
Aneurism 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[The effect of benzydamine on the generation and interaction of reactive oxygen species and cyclo- and lipoxygenase].
lipoxygenase Binding (interaction) of
1) Confidence 0.10 Published 1987 Journal Arzneimittelforschung Section Title Doc Link 3040020 Disease Relevance 0.19 Pain Relevance 0.38
BW775C was also analgesic, but inhibited cyclo-oxygenase, 5-lipoxygenase and 12-HETE formation.
lipoxygenase Binding (formation) of associated with analgesic
2) Confidence 0.09 Published 1988 Journal J Pharmacol Methods Section Abstract Doc Link 3145369 Disease Relevance 0 Pain Relevance 0.57
AA can be metabolized by three major oxidative pathways: cyclooxygenase (COX), forming prostaglandins and related eicosanoids; lipoxygenase (LOX), forming leukotrienes and related compounds; and cytochrome P450 (CYP450) monooxygenase, forming epoxides and alcohols such as 20-HETE (Fig. 1).
lipoxygenase Binding (compounds) of
3) Confidence 0.03 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.46 Pain Relevance 0.08

General Comments

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