INT34579

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.63
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGLL1)
Anatomy Link Frequency
B cells 2
lymphocyte 1
osteoclast 1
IGLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 100.00 Very High Very High Very High
spinal inflammation 1 96.56 Very High Very High Very High
cINOD 15 95.68 Very High Very High Very High
Arthritis 14 94.88 High High
metalloproteinase 2 89.04 High High
Inflammation 65 83.08 Quite High
rheumatoid arthritis 98 82.16 Quite High
psoriasis 4 69.84 Quite High
methotrexate 11 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 20 99.82 Very High Very High Very High
Hypercalcemia 1 98.14 Very High Very High Very High
Seronegative Spondarthritis 3 96.56 Very High Very High Very High
Klebsiella Infection 1 94.44 High High
Influenza Virus Infection 67 89.84 High High
Rheumatoid Arthritis 112 88.48 High High
Immunization 19 87.24 High High
Autoimmune Disease 18 83.88 Quite High
INFLAMMATION 66 83.08 Quite High
Arthritis 13 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proliferative response, as measured by thymidine uptake and the B-cell differentiation response, as measured by Ig secretion, have been studied in peripheral blood mononuclear cells obtained from patients with ankylosing spondylitis, Yersinia reactive arthritis, Klebsiella infections and healthy controls, following stimulation with enterobacterial biostructures.
Localization (secretion) of Ig in B-cell associated with seronegative spondarthritis, spinal inflammation, klebsiella infection and arthritis
1) Confidence 0.69 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3042075 Disease Relevance 0.36 Pain Relevance 0.14
This study investigated effects of indomethacin and a new NSAID (d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid, termed as M-5011 in this study) on cytokine production, lymphocyte proliferation, activities of natural killer (NK) and lymphokine activated killer (LAK) cells and secretion of immunoglobulin (Ig).
Localization (secretion) of Ig in lymphocyte associated with cinod and cytokine
2) Confidence 0.21 Published 1998 Journal Immunopharmacology Section Abstract Doc Link 9858064 Disease Relevance 0.24 Pain Relevance 0.66
In contrast, indomethacin was more potent than M-5011 in inhibition of both PG synthesis and Ig secretions by pokeweed mitogen (PWM)-stimulated PBMC.
Localization (secretions) of Ig
3) Confidence 0.21 Published 1998 Journal Immunopharmacology Section Abstract Doc Link 9858064 Disease Relevance 0.21 Pain Relevance 0.61
Importantly, there was no association between the incidence of serious infection and the presence of low Ig (including Ig isotypes).
Localization (presence) of Ig associated with infection
4) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2919195 Disease Relevance 0.43 Pain Relevance 0
However, the primary B cells do not secrete vaccine-specific Ig, because no antibody levels may be detected in the circulation.
Neg (not) Localization (secrete) of Ig in B cells
5) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.38 Pain Relevance 0.09
Cells secreting vaccine-specific Ig were enumerated 6 days after vaccination.
Localization (secreting) of Ig
6) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.25 Pain Relevance 0
Furthermore, IL-4 inhibits bone resorption through an effect on both osteoclast activity and survival [75] and reduces the spontaneous secretion of proinflammatory cytokines and Ig in ex vivo cultured pieces from the rheumatoid synovial membrane [76].
Localization (secretion) of Ig in osteoclast associated with hypercalcemia and cytokine
7) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.77 Pain Relevance 0.39

General Comments

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