INT34586

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.39
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 2
fat 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 3 99.18 Very High Very High Very High
rheumatoid arthritis 56 98.80 Very High Very High Very High
Paracetamol 38 92.88 High High
Inflammatory marker 2 90.88 High High
Pain 2 84.24 Quite High
transdermal 15 75.04 Quite High
Clonidine 2 72.80 Quite High
tolerance 2 52.88 Quite High
Calcium channel 1 25.00 Low Low
Angina 5 22.08 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 118 100.00 Very High Very High Very High
Hypertriglyceridemia 13 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

12 99.58 Very High Very High Very High
Rheumatoid Arthritis 56 98.80 Very High Very High Very High
Cardiovascular Disease 17 98.44 Very High Very High Very High
Disease 27 95.04 Very High Very High Very High
Hyperlipidemia 2 94.48 High High
INFLAMMATION 13 90.56 High High
Obesity 6 86.24 High High
Pain 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDL3 predominance in decreased HDL fraction and strongly decreased CE/TC ratio could be dependent of Apo C-I deficiency.
Positive_regulation (dependent) of Negative_regulation (predominance) of HDL associated with disorder of lipid metabolism
1) Confidence 0.49 Published 1986 Journal Clin. Chim. Acta Section Abstract Doc Link 3731486 Disease Relevance 0.37 Pain Relevance 0.08
Several beta-blockers given as monotherapy induce significant increases in Tg and a tendency for decreases in HDL-C.
Positive_regulation (increases) of Negative_regulation (decreases) of HDL associated with hypertriglyceridemia, beta blocker and disorder of lipid metabolism
2) Confidence 0.45 Published 1988 Journal Drugs Section Abstract Doc Link 3042351 Disease Relevance 0.64 Pain Relevance 0.16
Additionally, ezetimibe/simvastatin produced a significantly greater increase in HDL-C levels and comparable reductions in triglycerides and CRP compared with atorvastatin.
Positive_regulation (increase) of Negative_regulation (reductions) of HDL associated with disorder of lipid metabolism
3) Confidence 0.45 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.40 Pain Relevance 0
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Positive_regulation (increase) of Negative_regulation (decrease) of HDL associated with rheumatoid arthritis and disorder of lipid metabolism
4) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.46 Pain Relevance 0.31
In addition, testosterone replacement decreases lipoprotein (a).19 The mechanism of the fall in lipids might be related to the decrease in the visceral abdominal fat mass241 under the influence of androgens, which inhibit lipoprotein lipase activity and increase lipolysis242,243 with improvement of insulin sensitivity and mobilization of triglycerides from abdominal fat tissue.244 Supraphysiological T levels induce an increase in LDL-C and a decrease of HDL-C245–247 and may increase the risk of cardiovascular disease.
Positive_regulation (increase) of Negative_regulation (decrease) of HDL in fat associated with cardiovascular disease and disorder of lipid metabolism
5) Confidence 0.17 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 0.81 Pain Relevance 0.06
Table 1 indicates that the cholesterol-supplemented diet caused marked alterations in the plasma lipoproteins, particularly an increase of LDL and a decrease of HDL in comparison with the control group.
Positive_regulation (increase) of Negative_regulation (decrease) of HDL in plasma associated with disorder of lipid metabolism
6) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274992 Disease Relevance 0.52 Pain Relevance 0.43

General Comments

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