INT34590

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 199
Total Number 204
Disease Relevance 89.85
Pain Relevance 15.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 15
chondrocytes 5
blood 5
kidney 4
osteoclast 2
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 113 99.86 Very High Very High Very High
Inflammatory mediators 4 99.76 Very High Very High Very High
Paracetamol 109 99.74 Very High Very High Very High
Osteoarthritis 1394 99.52 Very High Very High Very High
Glutamate 15 99.28 Very High Very High Very High
imagery 327 99.12 Very High Very High Very High
Pain 199 98.92 Very High Very High Very High
COX-2 inhibitor 56 98.92 Very High Very High Very High
halothane 10 98.28 Very High Very High Very High
cytokine 313 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 1162 100.00 Very High Very High Very High
Body Weight 166 100.00 Very High Very High Very High
Nicotine Addiction 809 99.98 Very High Very High Very High
Carcinoma 69 99.98 Very High Very High Very High
Disease 495 99.92 Very High Very High Very High
Cancer 2216 99.88 Very High Very High Very High
Respiratory Syncytial Virus 697 99.88 Very High Very High Very High
Endometriosis (extended) 9 99.84 Very High Very High Very High
Calcification 44 99.80 Very High Very High Very High
Targeted Disruption 140 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Gene_expression (expression) of ALP in osteoclast associated with osteoporosis
1) Confidence 0.75 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.34 Pain Relevance 0.09
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Gene_expression (expression) of ALP
2) Confidence 0.75 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Gene_expression (expression) of alkaline phosphatase in osteoclast associated with osteoporosis
3) Confidence 0.75 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.35 Pain Relevance 0.09
Based on these characteristics and the observation that infants produce small amounts of PLAP compared to pregnant women, cord PLAP can be used as a surrogate marker of placental microtransfusions [13].
Gene_expression (produce) of PLAP
4) Confidence 0.73 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1285069 Disease Relevance 0.87 Pain Relevance 0.08
ADSCs mineralize their extracellular matrix (ECM) and show increased expression of osteocalcin and alkaline phosphatase (ALP).[12] These factors may make ADSCs a viable clinical alternative to BMSCs.
Gene_expression (expression) of ALP in extracellular matrix
5) Confidence 0.70 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.25 Pain Relevance 0.16
ADSCs mineralize their extracellular matrix (ECM) and show increased expression of osteocalcin and alkaline phosphatase (ALP).[12] These factors may make ADSCs a viable clinical alternative to BMSCs.
Gene_expression (expression) of alkaline phosphatase in extracellular matrix
6) Confidence 0.70 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.25 Pain Relevance 0.16
Both drugs also inhibited insulin- and 1,25-dihydroxycholecalciferol-stimulated alkaline phosphatase production and [3H]thymidine uptake by human osteoblasts.
Gene_expression (production) of alkaline phosphatase in osteoblasts
7) Confidence 0.67 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3044473 Disease Relevance 0.08 Pain Relevance 0.43
Tumor markers such as alpha-fetoprotein, human growth hormone, carcinoembryonic antigen, and placental alkaline phosphatase were negative.
Neg (negative) Gene_expression (negative) of placental alkaline phosphatase associated with cancer
8) Confidence 0.66 Published 2007 Journal Pediatr Neurosurg Section Abstract Doc Link 17627146 Disease Relevance 1.38 Pain Relevance 0.09
In Case 2, we had to resume her treatment twice to maintain normal levels of T-ALP and uNTX, and the relief of bone pain.
Gene_expression (levels) of T-ALP associated with pain
9) Confidence 0.66 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.16 Pain Relevance 0.16
The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4.
Gene_expression (immunoreactive) of PLAP associated with cancer
10) Confidence 0.65 Published 2008 Journal Diagn. Cytopathol. Section Abstract Doc Link 18773441 Disease Relevance 0.65 Pain Relevance 0.07
First, gestational age was directly correlated with cord PLAP activity, which is a result of the increase in maternal PLAP production over the course of a pregnancy [28].
Gene_expression (production) of PLAP
11) Confidence 0.63 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1285069 Disease Relevance 0.35 Pain Relevance 0
In these cells, low concentrations of melatonin increased the mRNA levels of several genes expressed in osteoblasts including bone sialoprotein (BSP), alkaline phosphatase (ALP), osteopontin and osteocalcin.[15] Several studies using various animal models show that melatonin prevents bone deterioration including preventing idiopathic scoliosis in adolescents[1316] and that it stimulates proliferation of normal cells such as human bone cells.[13] However, there are no reports of melatonin effects on ADSC osteogenic differentiation.
Gene_expression (expressed) of alkaline phosphatase in osteoblasts associated with scoliosis
12) Confidence 0.61 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.49 Pain Relevance 0.05
Hypocalcemia, hypophosphatemia, vitamin D deficiency, increased levels of alkaline phosphatase, and intact parathyroid hormone were noted.
Gene_expression (levels) of alkaline phosphatase in parathyroid associated with hypocalcemia and hypophosphatemia
13) Confidence 0.60 Published 2010 Journal J Clin Rheumatol Section Abstract Doc Link 20051755 Disease Relevance 0.71 Pain Relevance 0.12
They also had increased rates of collagen synthesis, alkaline phosphatase activity, and cell proliferation compared with the normal osteoblasts.
Gene_expression (synthesis) of alkaline phosphatase in osteoblasts
14) Confidence 0.57 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.57 Pain Relevance 0.06
Heterotopic ossification derived cells were shown to produce osteocalcin, Type 1 collagen, and alkaline phosphatase activity.
Gene_expression (produce) of alkaline phosphatase associated with heterotopic ossification
15) Confidence 0.57 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.58 Pain Relevance 0.07
Although heterotopic ossification derived cells functioned qualitatively like osteoblasts, they exhibited elevated levels of activities traditionally ascribed to osteoblasts, such as collagen synthesis and alkaline phosphatase activity.
Gene_expression (synthesis) of alkaline phosphatase in osteoblasts associated with heterotopic ossification
16) Confidence 0.57 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.46 Pain Relevance 0
The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4.
Gene_expression (immunoreactive) of placental-like alkaline phosphatase associated with cancer
17) Confidence 0.57 Published 2008 Journal Diagn. Cytopathol. Section Abstract Doc Link 18773441 Disease Relevance 0.65 Pain Relevance 0.07
A bone scintigraphy showed hot spots in her pelvic bone, and her T-ALP (593 IU/L) and uNTX (234.6 nMBCE/mM·Cr) levels were elevated as in the first patient.
Gene_expression (levels) of T-ALP in pelvic bone
18) Confidence 0.57 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.75 Pain Relevance 0.52
In contrast, our second patient (Case 2) was re-treated twice (Figure 2) for her increased T-ALP level.
Gene_expression (level) of T-ALP
19) Confidence 0.57 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.73 Pain Relevance 0.25
Our patient was diagnosed with PDB based on typical features such as radiographic osteolytic and sclerotic changes in the pelvic bone (Figure 1), bone scintigraphy showing hot spots in the affected bones, and markedly increased levels of T-ALP (1344 IU/lL; normal range 110-370 IU/L) and uNTX (213 nmol bone collagen/mmol·creatinine [nMBCE/mM·Cr]; normal range 9.3 to 54.3).
Gene_expression (levels) of T-ALP in pelvic bone
20) Confidence 0.57 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.60 Pain Relevance 0.46

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