INT34592

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 51
Total Number 52
Disease Relevance 20.62
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 12
chondrocytes 6
pelvic bone 4
osteoclast 4
blood 4
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 45 99.86 Very High Very High Very High
Paracetamol 36 99.78 Very High Very High Very High
Inflammatory mediators 2 99.76 Very High Very High Very High
Osteoarthritis 430 99.60 Very High Very High Very High
halothane 9 98.28 Very High Very High Very High
cytokine 88 98.20 Very High Very High Very High
anesthesia 13 97.64 Very High Very High Very High
COX-2 inhibitor 25 93.64 High High
dexamethasone 14 93.52 High High
Pain 73 93.16 High High
Disease Link Frequency Relevance Heat
Calcification 10 100.00 Very High Very High Very High
Respiratory Syncytial Virus 232 99.88 Very High Very High Very High
Death 19 99.74 Very High Very High Very High
Hepatotoxicity 17 99.70 Very High Very High Very High
Osteoarthritis 439 99.60 Very High Very High Very High
Hypophosphatemia 1 99.52 Very High Very High Very High
Nicotine Addiction 93 99.48 Very High Very High Very High
INFLAMMATION 72 99.36 Very High Very High Very High
Hypocalcemia 1 99.16 Very High Very High Very High
Osteoporosis 293 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Positive_regulation (induces) of Gene_expression (expression) of ALP
1) Confidence 0.67 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Positive_regulation (inducing) of Gene_expression (expression) of alkaline phosphatase in osteoclast associated with osteoporosis
2) Confidence 0.67 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.35 Pain Relevance 0.09
ADSCs mineralize their extracellular matrix (ECM) and show increased expression of osteocalcin and alkaline phosphatase (ALP).[12] These factors may make ADSCs a viable clinical alternative to BMSCs.
Positive_regulation (increased) of Gene_expression (expression) of ALP in extracellular matrix
3) Confidence 0.63 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.25 Pain Relevance 0.16
Both drugs also inhibited insulin- and 1,25-dihydroxycholecalciferol-stimulated alkaline phosphatase production and [3H]thymidine uptake by human osteoblasts.
Positive_regulation (stimulated) of Gene_expression (production) of alkaline phosphatase in osteoblasts
4) Confidence 0.60 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3044473 Disease Relevance 0.08 Pain Relevance 0.43
First, gestational age was directly correlated with cord PLAP activity, which is a result of the increase in maternal PLAP production over the course of a pregnancy [28].
Positive_regulation (increase) of Gene_expression (production) of PLAP
5) Confidence 0.57 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1285069 Disease Relevance 0.35 Pain Relevance 0
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Positive_regulation (inducing) of Gene_expression (expression) of ALP in osteoclast associated with osteoporosis
6) Confidence 0.48 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.35 Pain Relevance 0.09
Hypocalcemia, hypophosphatemia, vitamin D deficiency, increased levels of alkaline phosphatase, and intact parathyroid hormone were noted.
Positive_regulation (increased) of Gene_expression (levels) of alkaline phosphatase in parathyroid associated with hypocalcemia and hypophosphatemia
7) Confidence 0.47 Published 2010 Journal J Clin Rheumatol Section Abstract Doc Link 20051755 Disease Relevance 0.71 Pain Relevance 0.12
ADSCs mineralize their extracellular matrix (ECM) and show increased expression of osteocalcin and alkaline phosphatase (ALP).[12] These factors may make ADSCs a viable clinical alternative to BMSCs.
Positive_regulation (increased) of Gene_expression (expression) of alkaline phosphatase in extracellular matrix
8) Confidence 0.45 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.25 Pain Relevance 0.16
In these cells, low concentrations of melatonin increased the mRNA levels of several genes expressed in osteoblasts including bone sialoprotein (BSP), alkaline phosphatase (ALP), osteopontin and osteocalcin.[15] Several studies using various animal models show that melatonin prevents bone deterioration including preventing idiopathic scoliosis in adolescents[1316] and that it stimulates proliferation of normal cells such as human bone cells.[13] However, there are no reports of melatonin effects on ADSC osteogenic differentiation.
Positive_regulation (increased) of Gene_expression (expressed) of alkaline phosphatase in osteoblasts associated with scoliosis
9) Confidence 0.45 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.50 Pain Relevance 0.10
Although heterotopic ossification derived cells functioned qualitatively like osteoblasts, they exhibited elevated levels of activities traditionally ascribed to osteoblasts, such as collagen synthesis and alkaline phosphatase activity.
Positive_regulation (elevated) of Gene_expression (synthesis) of alkaline phosphatase in osteoblasts associated with heterotopic ossification
10) Confidence 0.43 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.47 Pain Relevance 0.05
They also had increased rates of collagen synthesis, alkaline phosphatase activity, and cell proliferation compared with the normal osteoblasts.
Positive_regulation (increased) of Gene_expression (synthesis) of alkaline phosphatase in osteoblasts
11) Confidence 0.43 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.58 Pain Relevance 0.07
In contrast, our second patient (Case 2) was re-treated twice (Figure 2) for her increased T-ALP level.
Positive_regulation (increased) of Gene_expression (level) of T-ALP
12) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.73 Pain Relevance 0.25
A bone scintigraphy showed hot spots in her pelvic bone, and her T-ALP (593 IU/L) and uNTX (234.6 nMBCE/mM·Cr) levels were elevated as in the first patient.
Positive_regulation (elevated) of Gene_expression (levels) of T-ALP in pelvic bone
13) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.81 Pain Relevance 0.57
Our patient was diagnosed with PDB based on typical features such as radiographic osteolytic and sclerotic changes in the pelvic bone (Figure 1), bone scintigraphy showing hot spots in the affected bones, and markedly increased levels of T-ALP (1344 IU/lL; normal range 110-370 IU/L) and uNTX (213 nmol bone collagen/mmol·creatinine [nMBCE/mM·Cr]; normal range 9.3 to 54.3).
Positive_regulation (increased) of Gene_expression (levels) of T-ALP in pelvic bone
14) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.61 Pain Relevance 0.46
90th percentile for the ICA-PLAP assay and the 100th
Positive_regulation (percentile) of Gene_expression (assay) of PLAP
15) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.15 Pain Relevance 0
developed assays could also be used to detect PLAP/PLAP-like
Positive_regulation (used) of Gene_expression (detect) of PLAP
16) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.83 Pain Relevance 0.03
Since PLAP/PLAP-like activity could be detected at very low levels
Positive_regulation (Since) of Gene_expression (activity) of PLAP
17) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.74 Pain Relevance 0
ICA-PLAP and ICA-PEP assays showed no difference between
Positive_regulation (-) of Gene_expression (assays) of PLAP
18) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.47 Pain Relevance 0
Exposure to 10 µM and 100 µM diazoxide caused upregulation of ALP expression by 2.9-fold and 2.1-fold, respectively, and upregulation of BSP expression by 4.3-fold and 3.1-fold, respectively (Fig. 10C, p<0.05).
Positive_regulation (upregulation) of Gene_expression (expression) of ALP
19) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Treatment was interrupted for one dalcetrapib participant due to increased (>3 × ULN) levels of alkaline phosphatase (ALP), ALT, and gamma-glutamyl transferase (GGT) on Day 19.
Positive_regulation (increased) of Gene_expression (levels) of ALP
20) Confidence 0.28 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.58 Pain Relevance 0

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