INT345925

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) small molecule metabolic process (CYP1A2) oxidoreductase activity (CYP1A2)
aging (IL6) extracellular region (IL6) endoplasmic reticulum (CYP1A2)
IL6 (Homo sapiens)
CYP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 52 64.00 Quite High
methotrexate 53 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 64.00 Quite High
Body Weight 2 62.92 Quite High
Disease 22 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Coronary Artery Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Fatigue 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 reduces mRNA expression for several cytochrome (CYP)450 isoenzymes (CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) in vitro, and this is reversed by coincubation with TCZ at clinically relevant concentrations.
IL-6 Negative_regulation (reduces) of Gene_expression (expression) of CYP1A2
1) Confidence 0.13 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.18 Pain Relevance 0.06

General Comments

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