INT345936

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) cytoskeleton (JAK3) cytoplasm (JAK3)
Anatomy Link Frequency
B lymphocytes 1
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 100.00 Very High Very High Very High
tolerance 1 94.40 High High
rheumatoid arthritis 52 82.32 Quite High
antagonist 1 81.68 Quite High
anakinra 1 80.80 Quite High
Inflammation 4 79.36 Quite High
abatacept 2 67.20 Quite High
Adalimumab 1 30.00 Quite Low
Infliximab 1 27.48 Quite Low
Etanercept 1 22.24 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 82.32 Quite High
INFLAMMATION 6 79.36 Quite High
Disease 22 54.00 Quite High
Necrosis 1 26.16 Quite Low
Cancer 1 25.80 Quite Low
Infection 10 5.00 Very Low Very Low Very Low
Coronary Artery Disease 7 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Fatigue 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some that are currently in development and at the trial stages are agents targeting IL-1, cytokines from the TNF superfamily, IL-15, IL-17, B lymphocytes, IL-12/IL-23, SyK kinase, JAK3 kinase, and inhibitors of osteoclastogenesis.40–51

Chemistry and mechanism of action

Regulation (targeting) of JAK3 kinase in B lymphocytes associated with cytokine
1) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.41 Pain Relevance 0.46

General Comments

This test has worked.

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