INT34594

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 5.04
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
chondrocytes 2
stromal cells 2
Monocytes 2
thyroid 2
osteoblasts 2
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 29 100.00 Very High Very High Very High
halothane 9 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
COX-2 inhibitor 15 94.04 High High
aspirin 5 93.16 High High
cINOD 22 90.88 High High
imagery 22 79.92 Quite High
Osteoarthritis 133 65.60 Quite High
withdrawal 13 34.72 Quite Low
depression 2 15.76 Low Low
Disease Link Frequency Relevance Heat
Cancer 283 99.98 Very High Very High Very High
Embryonal Carcinoma 35 99.92 Very High Very High Very High
Seminoma 30 99.40 Very High Very High Very High
Thyroid Neoplasm 23 97.56 Very High Very High Very High
Nicotine Addiction 65 95.52 Very High Very High Very High
Osteoporosis 125 95.00 High High
Adhesions 1 95.00 High High
Postmenopausal Osteoporosis 6 94.96 High High
Germ Cell And Embryonal Neoplasms 5 88.08 High High
Rheumatoid Arthritis 11 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both drugs also inhibited insulin- and 1,25-dihydroxycholecalciferol-stimulated alkaline phosphatase production and [3H]thymidine uptake by human osteoblasts.
Negative_regulation (inhibited) of Gene_expression (production) of alkaline phosphatase in osteoblasts
1) Confidence 0.50 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3044473 Disease Relevance 0.08 Pain Relevance 0.44
In addition, as with AD differentiation, a four-day exposure to the treatments resulted in larger decreases in both ALP expression (3.8- and 9.2-fold for ouabain and K+, respectively, p<0.0001) and BSP expression by Day 7 (5.7-fold decrease for ouabain, p<0.0004, and undetectable levels for K+) (Fig. 9B, right).
Negative_regulation (decreases) of Gene_expression (expression) of ALP
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Following the first cycle of chemotherapy, PLAP/PLAP-like serum
Negative_regulation (Following) of Gene_expression (serum) of PLAP
3) Confidence 0.25 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.87 Pain Relevance 0.04
PLAP/PLAP-like activity determined by
Spec (determined) Negative_regulation (determined) of Spec (determined) Gene_expression (activity) of PLAP
4) Confidence 0.25 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.06 Pain Relevance 0.03
The ICA-PLAP and ICA-PEP immunoassays could be explored to detect
Negative_regulation (explored) of Gene_expression (immunoassays) of PLAP
5) Confidence 0.25 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.26 Pain Relevance 0.07
Since PLAP/PLAP-like activity could be detected at very low levels
Negative_regulation (detected) of Gene_expression (activity) of PLAP
6) Confidence 0.25 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.75 Pain Relevance 0
complete tumor regression, and the hPLAP/PLAP-like enzyme activity
Negative_regulation (regression) of Gene_expression (activity) of hPLAP associated with cancer
7) Confidence 0.22 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.24 Pain Relevance 0.04
However, the decreased bALP expression induced by NS-398 could be due also to the decreased viability of bALP-expressing cells, in addition to the effect on reduced osteogenic differentiation of mesenchymal precursors.
Negative_regulation (decreased) of Gene_expression (expression) of bALP
8) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.31 Pain Relevance 0.08
We observed a significant decrease in b-ALP gene expression (and obviously in COX-2 gene expression) in cells treated with NS-398, confirming a reduced recruitment of stromal cells to osteoblastic lineage.
Negative_regulation (decrease) of Gene_expression (expression) of ALP in stromal cells associated with osteoporosis
9) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.15 Pain Relevance 0.03
The addition of NS-398 inhibitor decreased significantly the Ris-induced COX2 and b-ALP gene overexpression.



Negative_regulation (decreased) of Gene_expression (overexpression) of ALP associated with cox2
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.39 Pain Relevance 0.05
Monocytes also increased the levels of alkaline phosphatase (ALP) staining in MSCs and prevented the decrease in ALP expression induced by IL-2 activated NK cells (data not shown).
Negative_regulation (decrease) of in NK cells Gene_expression (expression) of ALP in Monocytes
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0
Monocytes also increased the levels of alkaline phosphatase (ALP) staining in MSCs and prevented the decrease in ALP expression induced by IL-2 activated NK cells (data not shown).
Negative_regulation (prevented) of in NK cells Gene_expression (expression) of ALP in Monocytes
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0
Additionally, retinoids exert several re-differentiating effects: induction of 5'-DI [12,13] increased expression of NIS mRNA [14] and of the differentiation marker, alkaline phosphatase, or decreased expression of CD97, which is highly expressed in anaplastic thyroid carcinoma [15], as well as stimulation of intercellular adhesion molecule-1 synthesis [16].
Negative_regulation (decreased) of Gene_expression (expression) of alkaline phosphatase in thyroid associated with thyroid neoplasm and adhesions
13) Confidence 0.06 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.68 Pain Relevance 0
Activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase enzymes were significantly increased (p < 0.05, p < 0.01, p < 0.05, respectively) by halothane anesthesia, but decreased (p < 0.05, p < 0.05, p < 0.05, respectively) with administration of vitamin C.
Negative_regulation (decreased) of Gene_expression (Activities) of alkaline phosphatase associated with anesthesia and halothane
14) Confidence 0.03 Published 2005 Journal Gen. Physiol. Biophys. Section Abstract Doc Link 15900086 Disease Relevance 0.07 Pain Relevance 0.58
Alkaline phosphatase expression was increased in ipsilateral chondrocytes by 8 weeks, increased dramatically at 12 weeks, and diminished thereafter (Figure 9b).
Negative_regulation (diminished) of Gene_expression (expression) of Alkaline phosphatase in chondrocytes
15) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.19 Pain Relevance 0.06

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