INT34595

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.29
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Reg1)
Anatomy Link Frequency
PSP 2
vesicles 1
Reg1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 99.60 Very High Very High Very High
Action potential 6 99.50 Very High Very High Very High
COX-2 inhibitor 1 98.08 Very High Very High Very High
tetrodotoxin 9 97.84 Very High Very High Very High
Enkephalin 7 97.62 Very High Very High Very High
Inflammation 3 94.48 High High
antagonist 2 93.68 High High
Neurotransmitter 5 93.52 High High
Analgesic 1 93.12 High High
Nicotine 1 89.00 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 99.72 Very High Very High Very High
Alzheimer's Dementia 4 99.42 Very High Very High Very High
INFLAMMATION 4 99.32 Very High Very High Very High
Calcification 2 98.28 Very High Very High Very High
Exocrine Pancreatic Insufficiency 2 97.96 Very High Very High Very High
Anaerobic Bacterial Infections 6 97.84 Very High Very High Very High
Calculi 2 96.44 Very High Very High Very High
Appetite Loss 2 95.92 Very High Very High Very High
Pancreatitis 16 95.08 Very High Very High Very High
Insulin Resistance 1 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of all-or-none failures of the presynaptic action potential results in even greater suppression of PTP.
Negative_regulation (suppression) of PTP associated with action potential
1) Confidence 0.36 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4056860 Disease Relevance 0.14 Pain Relevance 0.36
At longer exposures and higher DPH concentrations EPP failures did develop, and this was associated with a more profound suppression of PTP.
Negative_regulation (suppression) of PTP
2) Confidence 0.36 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4056860 Disease Relevance 0.24 Pain Relevance 0.35
DPH reduced PTP even when there was no failure of the EPP during the tetanus.
Negative_regulation (reduced) of PTP associated with anaerobic bacterial infections
3) Confidence 0.26 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4056860 Disease Relevance 0.24 Pain Relevance 0.22
Recent literature indicates that a decrease in the activity of pancreatic stone protein (PSP), which inhibits CaCO3 crystal formation in pancreatic juice, is closely related to the development of chronic calcifying pancreatitis.
Negative_regulation (decrease) of pancreatic stone protein in PSP associated with pancreatitis
4) Confidence 0.17 Published 1993 Journal Dig. Dis. Sci. Section Abstract Doc Link 8482198 Disease Relevance 0.78 Pain Relevance 0.08
Recent literature indicates that a decrease in the activity of pancreatic stone protein (PSP), which inhibits CaCO3 crystal formation in pancreatic juice, is closely related to the development of chronic calcifying pancreatitis.
Negative_regulation (decrease) of PSP in PSP associated with pancreatitis
5) Confidence 0.17 Published 1993 Journal Dig. Dis. Sci. Section Abstract Doc Link 8482198 Disease Relevance 0.78 Pain Relevance 0.08
E-64c, a selective cysteine protease inhibitor, was the most effective inhibitor of PTP with a second-order rate constant of inactivation, kappa 2, of 6,710,000 M-1S-1.
Negative_regulation (inhibitor) of PTP
6) Confidence 0.14 Published 1994 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 7944391 Disease Relevance 0 Pain Relevance 0
The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP).
Negative_regulation (inhibits) of PTP associated with alzheimer's dementia
7) Confidence 0.04 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 9915856 Disease Relevance 0.18 Pain Relevance 0.20
These results suggest a role for KPI/APP inhibition of PTP in regulated secretory vesicles.
Negative_regulation (inhibition) of PTP in vesicles
8) Confidence 0.04 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915856 Disease Relevance 0.14 Pain Relevance 0.25
Either a deficiency in pancreatic stone protein, or the toxic effect of cyanogen glucosides present in cassava and other tropical foodstuffs, or the malnutrition-related deficiency in sulphur-containing aminoacids may be causal factors.
Negative_regulation (deficiency) of pancreatic stone protein associated with appetite loss
9) Confidence 0.04 Published 1988 Journal Diabete Metab Section Abstract Doc Link 3044866 Disease Relevance 1.12 Pain Relevance 0.07
A role for PTP in cellular proenkephalin processing is suggested by blockade of forskolin-stimulated (Met)enkephalin production by Ep453 that is converted intracellularly to E-64c, a selective cysteine protease inhibitor that potently inhibits PTP.
Negative_regulation (inhibits) of PTP associated with enkephalin
10) Confidence 0.02 Published 1994 Journal FASEB J. Section Abstract Doc Link 8001739 Disease Relevance 0 Pain Relevance 0.24
Islet-activation protein (IAP), a G-protein inhibitor, completely blocked the suppressive effect of ACh.
Negative_regulation (inhibitor) of Islet-activation protein
11) Confidence 0.00 Published 1997 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9577658 Disease Relevance 0.26 Pain Relevance 0.47
Selective inhibitors of cyclooxygenase-2 (COX-2) were designed to minimize gastrointestinal complications of traditional non-steroidal anti-inflammatory drugs (NSAIDs) attributed to the suppression of COX-1-derived prostanoids.
Negative_regulation (suppression) of COX-1-derived associated with inflammation and cinod
12) Confidence 0.00 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17691994 Disease Relevance 0.41 Pain Relevance 0.45

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