INT345953

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Ahi1) cytoskeleton (Ahi1) cilium (Ahi1)
cytoplasm (Ahi1)
Anatomy Link Frequency
pharynx 1
body 1
Ahi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 60 5.00 Very Low Very Low Very Low
anesthesia 35 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Regional anesthesia 5 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
epidural 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
backache 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apnoea 35 100.00 Very High Very High Very High
Disease 30 100.00 Very High Very High Very High
Sleep Disorders 20 100.00 Very High Very High Very High
Body Weight 25 99.96 Very High Very High Very High
Weight Loss 35 98.88 Very High Very High Very High
Obesity 835 96.34 Very High Very High Very High
Insulin Resistance 15 90.64 High High
Diabetes Mellitus 20 89.84 High High
Cardiovascular Disease 20 89.28 High High
Shock 5 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, two patients were found to have an increase in their AHI despite significant weight loss.26 A meta-analysis by Greenburg et al39 representing 342 patients in the year 2009, showed similar results with bariatric surgery significantly reducing AHI, however, to a mean value still consistent with moderately severe OSA.39
Negative_regulation (reducing) of AHI associated with weight loss
1) Confidence 0.08 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.87 Pain Relevance 0
A number of studies have focused on diet-induced weight loss, achieving promising results in patients who underwent intensive weight management programs with moderate reductions in overall weight and AHI.
Negative_regulation (reductions) of AHI associated with weight loss
2) Confidence 0.06 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.62 Pain Relevance 0
Reducing disease severity to an AHI of <15 events per hour (ie, mild OSA) through weight loss can help in achieving improved outcomes in OSA patients.40 A continual effort to lose weight could also help in preventing the emergence of associated medical conditions like insulin resistance, diabetes, and cardiovascular diseases.


Negative_regulation (Reducing) of AHI associated with weight loss, cardiovascular disease, diabetes mellitus, insulin resistance and disease
3) Confidence 0.06 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.28 Pain Relevance 0
For the same reductions in body weight, AHI decreases at a much lower rate.36,37 Weight loss can be difficult to achieve and even harder to maintain.
Negative_regulation (decreases) of AHI in body associated with weight loss and body weight
4) Confidence 0.06 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.01 Pain Relevance 0
Obesity-related reductions in lung volumes (ie, FRC and TLC) also increase passive closing pressures at the pharynx.32 Heinzer et al33 demonstrated that a 1.3 L increase in FRC during sleep decreased the apnea/hypopnea index (AHI) from 62.3 events per hour to 31.2 events per hour.
Negative_regulation (decreased) of AHI in pharynx associated with apnoea, obesity and sleep disorders
5) Confidence 0.06 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.89 Pain Relevance 0

General Comments

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