INT345957

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.03
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
melanocyte 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 86.16 High High
agonist 4 84.88 Quite High
melanocortin 1 receptor 3 83.00 Quite High
adenocard 1 78.36 Quite High
Inflammation 49 71.88 Quite High
Inflammatory stimuli 4 66.12 Quite High
cytokine 10 62.36 Quite High
Inflammatory marker 4 56.60 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 178 100.00 Very High Very High Very High
Hypercapnia 10 99.84 Very High Very High Very High
Weight Gain 6 95.16 Very High Very High Very High
Obesity-hypoventilation Syndrome 28 76.80 Quite High
Pulmonary Disease 25 72.24 Quite High
INFLAMMATION 58 71.88 Quite High
Hypoventilation 1 65.68 Quite High
Stress 4 49.12 Quite Low
Apnoea 7 34.08 Quite Low
Snoring 3 33.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leptin-deficient obese mice were observed to have a reduced ventilatory drive in response to hypercapnia, which subsequently improved on administration of leptin.43
Positive_regulation (response) of Leptin Binding (have) of associated with hypercapnia and obesity
1) Confidence 0.38 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.58 Pain Relevance 0.04
POMC is upregulated in response to leptin binding and is proteolitically cleaved into several active peptides, including alpha melanocyte stimulating hormone (?
Positive_regulation (upregulated) of leptin Binding (binding) of in melanocyte
2) Confidence 0.21 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.46 Pain Relevance 0.56

General Comments

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