INT34597

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.54
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Des) cytoskeleton (Des) intracellular (Des)
cytoplasm (Des)
Anatomy Link Frequency
embryos 1
muscle 1
PSCs 1
reproductive tract 1
Des (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 7 95.76 Very High Very High Very High
Potency 54 88.76 High High
Chronic pancreatitis 1 85.72 High High
tetrodotoxin 5 78.32 Quite High
fibrosis 2 76.56 Quite High
Spinal cord 1 62.00 Quite High
imagery 30 50.00 Quite Low
addiction 2 50.00 Quite Low
agonist 6 35.28 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 121 99.72 Very High Very High Very High
Spontaneous Abortion 6 99.56 Very High Very High Very High
Congenital Anomalies 23 99.20 Very High Very High Very High
Cancer 12 98.48 Very High Very High Very High
Injury 3 97.92 Very High Very High Very High
Shock 151 97.12 Very High Very High Very High
Dysmenorrhea 7 95.76 Very High Very High Very High
Pancreatitis 1 85.72 High High
Stress 23 81.64 Quite High
Fibrosis 2 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After fusion only desmin expression is revealed.
Gene_expression (expression) of desmin
1) Confidence 0.75 Published 1988 Journal Dev. Biol. Section Abstract Doc Link 3044880 Disease Relevance 0.31 Pain Relevance 0.30
Although tamoxifen induces inner myometrial changes including that of ACTA2, desmin, ESR1 and laminin expression in C57/BL6J neonatal mice similar to those induced in CD-1 mice, C57/BL6J mice did not develop premature adenomyosis.
Gene_expression (expression) of desmin associated with dismenorea
2) Confidence 0.75 Published 2010 Journal Reproduction Section Abstract Doc Link 20368191 Disease Relevance 0.24 Pain Relevance 0.32
Eight weeks after BM transplantation, BM-derived cells accounted for 8.7% of the desmin (a marker of PSCs)-positive cells in the pancreas.
Gene_expression (positive) of desmin in PSCs
3) Confidence 0.58 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19808658 Disease Relevance 0.31 Pain Relevance 0.16
SRF plays a prominent role in regulating the expression of heart muscle genes [33] and may explain increases in muscle contraction genes (ACTA1, ACTA2, DES, MYL1, MYL2, MYL3, MYL9, MYOM1, TNNC2, TNNT1, TNNT3, TPM2, TPM4) after HS.
Gene_expression (expression) of DES in muscle associated with shock
4) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.75 Pain Relevance 0
7 M for DES, EP, and BPA, respectively.
Gene_expression (respectively) of DES
5) Confidence 0.16 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.18 Pain Relevance 0.09
For DES doses of 100 and 1,000 ?
Gene_expression (doses) of DES
6) Confidence 0.16 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.07 Pain Relevance 0
From measurements taken after mice pregnant with transgenic embryos were exposed to DES and EP, it was possible to evaluate the ability of the in vivo model to detect well-known estrogens in embryos exposed in utero.
Gene_expression (exposed) of DES in embryos associated with targeted disruption
7) Confidence 0.16 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.10 Pain Relevance 0
Children exposed to DES in utero developed abnormalities and cancer of the reproductive tract, whereas these effects were not found in their mothers (Herbst et al. 1971; McLachlan et al. 1975).
Gene_expression (exposed) of DES in reproductive tract associated with cancer and congenital anomalies
8) Confidence 0.16 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.43 Pain Relevance 0.04
The kinetics of luciferase induction by BPA, measured with the IVIS system, resemble the profile of DES.
Gene_expression (profile) of DES
9) Confidence 0.16 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.06 Pain Relevance 0.04
In rhesus monkeys, placental transfer of 14C-DES and 14C-E2 was similar (Hill et al. 1980).
Gene_expression (transfer) of DES
10) Confidence 0.14 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0

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