INT346123

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
T cells 4
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 196 98.96 Very High Very High Very High
Inflammation 41 98.92 Very High Very High Very High
cytokine 69 98.20 Very High Very High Very High
psoriasis 6 90.60 High High
Crohn's disease 52 84.84 Quite High
chemokine 4 70.76 Quite High
Arthritis 16 57.52 Quite High
cINOD 1 25.92 Quite Low
Multiple sclerosis 2 20.08 Low Low
methotrexate 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 196 98.96 Very High Very High Very High
INFLAMMATION 38 98.92 Very High Very High Very High
Psoriasis 6 90.60 High High
Disease 89 84.84 Quite High
Inflammatory Bowel Disease 54 74.88 Quite High
Apoptosis 2 59.76 Quite High
Arthritis 14 57.52 Quite High
Cancer 7 50.00 Quite Low
Necrosis 6 50.00 Quite Low
Ileal Diseases 5 33.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Negative_regulation (levels) of Gene_expression (expression) of IL22 associated with cytokine
1) Confidence 0.30 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.44
In contrast to the pattern of IL-22 expression, the majority of IL-17-producing CD4 T cells in SF coexpressed TNF?
Negative_regulation (pattern) of Gene_expression (expression) of IL-22 in T cells
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.33 Pain Relevance 0.14
IL-22 production by Th17 cells has been shown to be dependent upon IL-23 [38,45,46], thus our observation, which corroborates that of Shen et al. [25], that very few IL-17-producing CD4 T cells express IL-23R provides a potential explanation for the paucity of IL-22-positive IL-17-positive CD4 T cells we observed.
Negative_regulation (dependent) of Gene_expression (production) of IL-22 in T cells
3) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.74 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox