INT346192

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (RAMP2) signal transduction (RAMP2) plasma membrane (RAMP2)
lysosome (RAMP2) cytoplasm (RAMP2)
RAMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 98.52 Very High Very High Very High
Osteoarthritis 27 91.72 High High
rheumatoid arthritis 75 90.88 High High
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 27 91.72 High High
Rheumatoid Arthritis 75 90.88 High High
Adhesions 75 88.64 High High
Cancer 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Integrin activation was mediated by the adrenomedullin receptors CLR/RAMP, because it was inhibited by the receptor antagonist (22-52)AM, by inhibition of PKA, a downstream signaling molecule, and by inhibition of RAMP-2 by siRNA.
Negative_regulation (inhibition) of RAMP-2 associated with antagonist
1) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.92 Pain Relevance 0.42

General Comments

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