INT346196

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (AMELX, CRP) cell proliferation (AMELX) extracellular space (CRP)
signal transduction (AMELX) cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
Anatomy Link Frequency
joints 1
AMELX (Homo sapiens)
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
rheumatoid arthritis 33 63.68 Quite High
anakinra 1 62.88 Quite High
Inflammation 12 15.36 Low Low
methotrexate 13 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
Acute-phase Reaction 1 99.86 Very High Very High Very High
Rheumatoid Arthritis 33 63.68 Quite High
Congenital Anomalies 3 43.84 Quite Low
Infection 9 19.72 Low Low
INFLAMMATION 14 15.36 Low Low
Disease 17 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Hepatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that the components of the ACR responses showing dose-dependent effects in this study were those that are consistent with the known functions of IL-1 in pain [22] and in the acute phase response [23]: AMG 108 decreased pain, tender joints, ESR, and CRP.
AMG Negative_regulation (decreased) of CRP in joints associated with pain and acute-phase reaction
1) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991028 Disease Relevance 0.36 Pain Relevance 0.26

General Comments

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