INT346201

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 94.72 High High
methotrexate 26 85.12 High High
Arthritis 20 80.12 Quite High
antagonist 4 74.80 Quite High
Inflammation 24 73.08 Quite High
Potency 2 39.64 Quite Low
Pain 12 32.64 Quite Low
metalloproteinase 4 27.84 Quite Low
cytokine 8 21.96 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 66 94.72 High High
Disease 34 81.40 Quite High
Juvenile Chronic Polyarthritis 4 80.12 Quite High
INFLAMMATION 28 73.08 Quite High
Arthritis 14 68.52 Quite High
Experimental Arthritis 2 62.04 Quite High
Targeted Disruption 2 60.92 Quite High
Infection 18 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMG 108 (Amgen Inc., Thousand Oaks, CA, USA) is a fully human IgG2 monoclonal antibody that binds IL-1R type 1 and nonselectively inhibits the activity of both forms of IL-1 (IL-1?
Negative_regulation (inhibits) of Phosphorylation (forms) of IL-1
1) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991028 Disease Relevance 0.85 Pain Relevance 0.51
AMG 108 (Amgen Inc., Thousand Oaks, CA, USA) is a fully human IgG2 monoclonal antibody that binds IL-1R type 1 and nonselectively inhibits the activity of both forms of IL-1 (IL-1?
Negative_regulation (inhibits) of Phosphorylation (forms) of IL-1
2) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991028 Disease Relevance 0.85 Pain Relevance 0.51

General Comments

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