INT346212

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.70
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S100A10)
S100A10 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 370 99.68 Very High Very High Very High
spinal inflammation 50 99.40 Very High Very High Very High
Arthritis 50 98.20 Very High Very High Very High
Inflammation 35 5.00 Very Low Very Low Very Low
cytokine 25 5.00 Very Low Very Low Very Low
psoriasis 10 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 370 99.68 Very High Very High Very High
Low Back Pain 50 99.40 Very High Very High Very High
Arthritis 60 98.20 Very High Very High Very High
Disease 10 45.04 Quite Low
INFLAMMATION 25 5.00 Very Low Very Low Very Low
Sarcoma 15 5.00 Very Low Very Low Very Low
Psoriasis 10 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Arthropathy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified two linear peptides on BRAF, P10 and P25, recognized preferentially by RA patients.
P10 Binding (recognized) of associated with rheumatoid arthritis
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.15 Pain Relevance 0.62
Indeed, 35% of RA patients' sera recognized P10 versus 18% of AS patients (P = 0.01), 4% of PsA patients (P = 0.001) and 7% of healthy individuals (P = 0.00002).
P10 Binding (recognized) of associated with spinal inflammation, rheumatoid arthritis and arthritis
2) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.69 Pain Relevance 1.01
P10 is recognized by 35% of RA patients versus 11% of controls (P < 10-7, 180 RA patients versus 152 controls).
P10 Binding (recognized) of associated with rheumatoid arthritis
3) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.22 Pain Relevance 0.65
Four peptides, P10, P16, P25 and P33 were preferentially recognized by the sera of RA patients.
P10 Binding (recognized) of associated with rheumatoid arthritis
4) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.80 Pain Relevance 0.46
Indeed, 17 sera recognized P10, 8 recognized P16, 15 recognized P25, and 6 recognized P33 (Figure 1).


P10 Binding (recognized) of
5) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.83 Pain Relevance 0.49

General Comments

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