INT346217

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.23
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Braf, Map2k1) nucleus (Braf, Map2k1) plasma membrane (Braf, Map2k1)
kinase activity (Braf, Map2k1) Golgi apparatus (Map2k1) cell proliferation (Map2k1)
Braf (Mus musculus)
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 296 98.00 Very High Very High Very High
Inflammation 28 90.00 High High
cytokine 20 88.96 High High
Arthritis 40 84.68 Quite High
spinal inflammation 40 57.28 Quite High
psoriasis 8 53.36 Quite High
Kinase C 4 49.52 Quite Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 296 98.00 Very High Very High Very High
Disease 8 94.96 High High
INFLAMMATION 20 90.00 High High
Arthritis 48 87.04 High High
Death 4 68.72 Quite High
Low Back Pain 40 57.28 Quite High
Psoriasis 8 53.36 Quite High
Sarcoma 12 46.12 Quite Low
Arthropathy 4 9.68 Low Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that 65% of anti-BRAF autoantibodies activate phosphorylation of MEK1 by BRAF in vitro.
BRAF Positive_regulation (activate) of Phosphorylation (phosphorylation) of MEK1
1) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.82 Pain Relevance 0.50
No difference was observed in the recognition of BRAF peptides between autoantibodies to BRAF that inhibited or activated MEK1 phosphorylation (data not shown).


BRAF Positive_regulation (activated) of Phosphorylation (phosphorylation) of MEK1
2) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.62 Pain Relevance 0.22
Anti-BRAF autoantibodies activate the in vitro phosphorylation of MEK1 mediated by BRAF.


BRAF Positive_regulation (mediated) of Phosphorylation (phosphorylation) of MEK1
3) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991030 Disease Relevance 0.61 Pain Relevance 0.33
We found that anti-BRAF autoantibodies activate the in vitro phosphorylation of MEK1 mediated by BRAF.


BRAF Positive_regulation (mediated) of Phosphorylation (phosphorylation) of MEK1
4) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.18 Pain Relevance 0.68

General Comments

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