INT346225

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) cytoplasmic membrane-bounded vesicle (Flg)
plasma membrane (PRTN3) cytoskeleton organization (Flg) enzyme binding (PRTN3)
PRTN3 (Homo sapiens)
Flg (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 148 98.66 Very High Very High Very High
Inflammation 14 90.96 High High
Kinase C 2 49.20 Quite Low
spinal inflammation 20 29.68 Quite Low
Arthritis 20 23.72 Low Low
cytokine 10 21.68 Low Low
psoriasis 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 99.36 Very High Very High Very High
Rheumatoid Arthritis 148 98.66 Very High Very High Very High
Arthropathy 2 91.52 High High
INFLAMMATION 10 90.96 High High
Sarcoma 6 70.32 Quite High
Low Back Pain 20 29.68 Quite Low
Arthritis 24 23.72 Low Low
Psoriasis 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sera of patients with RA contain a family of highly disease-specific autoantibodies termed ACPA which recognize citrulline-centered peptidic epitopes on many proteins, like filaggrin, vimentin, and fibrin.
ACPA Binding (recognize) of filaggrin associated with rheumatoid arthritis and disease
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.81 Pain Relevance 0.31
ACPA recognize citrulline (a posttranslationally modified form of arginin) containing epitopes on various proteins, such as filaggrin, vimentin, and fibrinogen [3-6].
ACPA Binding (recognize) of filaggrin
2) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.93 Pain Relevance 0.38

General Comments

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