INT346229

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PREP, MAPK14) nucleus (PREP, MAPK14) cytoplasm (PREP, MAPK14)
nucleoplasm (MAPK14) signal transduction (MAPK14) peptidase activity (PREP)
Anatomy Link Frequency
chondrocytes 1
PREP (Homo sapiens)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 103 99.26 Very High Very High Very High
cytokine 8 54.16 Quite High
Inflammation 16 43.20 Quite Low
Arthritis 8 32.48 Quite Low
metalloproteinase 6 9.00 Low Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 104 99.26 Very High Very High Very High
Stress 1 46.08 Quite Low
INFLAMMATION 14 43.20 Quite Low
Arthritis 9 32.48 Quite Low
Disease 5 25.76 Quite Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in human OA chondrocytes has not been reported. p38-MAPK was not activated by treatment with PE alone but pretreatment of human OA chondrocytes with PE selectively inhibited the IL-1?
PE Neg (not) Positive_regulation (activated) of p38 in chondrocytes associated with osteoarthritis
1) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.34

General Comments

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