INT346229

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.34

cytosol (PREP, MAPK14) nucleus (PREP, MAPK14) cytoplasm (PREP, MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) peptidase activity (PREP)

Anatomy Link Frequency chondrocytes 1 PREP (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 99.26 cytokine 8 54.16 Inflammation 16 43.20 Arthritis 8 32.48 metalloproteinase 6 9.00 rheumatoid arthritis 4 5.00 Pain 2 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 99.26 Stress 1 46.08 INFLAMMATION 14 43.20 Arthritis 9 32.48 Disease 5 25.76 Rheumatoid Arthritis 4 5.00 Targeted Disruption 3 5.00 Pain 1 5.00 Apoptosis 1 5.00 Hypertrophy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

in human OA chondrocytes has not been reported. p38-MAPK was not activated by treatment with PE alone but pretreatment of human OA chondrocytes with PE selectively inhibited the IL-1?

PE Neg (not) Positive_regulation (activated) of p38 in chondrocytes associated with osteoarthritis

1) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.63 Pain Relevance 0.34

General Comments

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