INT346237

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.00 Pain Relevance 0.44

cytosol (MAP2K6, MAP2K3) nucleoplasm (MAP2K6, MAP2K3) signal transduction (MAP2K6, MAP2K3) cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)

Anatomy Link Frequency chondrocytes 1 MAP2K6 (Homo sapiens) MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 99.60 Inflammatory stimuli 1 86.04 Inflammation 16 66.36 cytokine 8 5.00 Arthritis 8 5.00 metalloproteinase 6 5.00 rheumatoid arthritis 4 5.00 Pain 2 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 99.60 INFLAMMATION 14 85.72 Disease 5 59.72 Arthritis 9 51.96 Rheumatoid Arthritis 4 5.00 Targeted Disruption 3 5.00 Pain 1 5.00 Apoptosis 1 5.00 Hypertrophy 1 5.00 Frailty 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

activates the p38-MAPK preferentially via the upstream kinase MKK3 compared to MKK6 in human OA chondrocytes.

MKK6 Positive_regulation (activates) of MKK3 in chondrocytes associated with osteoarthritis

1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.00 Pain Relevance 0.44

General Comments

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