INT34624

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.25
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (REM1) GTPase activity (REM1)
Anatomy Link Frequency
nucleus 1
stage 3 1
body 1
REM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 199 99.86 Very High Very High Very High
agonist 21 99.86 Very High Very High Very High
Clonidine 14 99.70 Very High Very High Very High
alcohol 61 99.28 Very High Very High Very High
tricyclic antidepressant 3 99.16 Very High Very High Very High
depression 222 96.52 Very High Very High Very High
Migraine 7 95.48 Very High Very High Very High
Thalamus 1 84.24 Quite High
Locus ceruleus 42 80.64 Quite High
Central nervous system 15 78.80 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 391 100.00 Very High Very High Very High
Premenstrual Syndrome 1133 99.86 Very High Very High Very High
Disease 84 99.64 Very High Very High Very High
Schizophrenia 203 98.36 Very High Very High Very High
Aging 5 98.36 Very High Very High Very High
Suicidal Behaviour 345 97.28 Very High Very High Very High
Depression 322 96.52 Very High Very High Very High
Headache 8 95.48 Very High Very High Very High
Congenital Anomalies 18 93.96 High High
Post-partum Depression 11 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, most drugs used on its treatment, such as tricyclic antidepressants and psychostimulant agents, are aimed to reduce REM sleep.
Negative_regulation (reduce) of REM associated with tricyclic antidepressant
1) Confidence 0.38 Published 1985 Journal Acta Psiquiatr Psicol Am Lat Section Abstract Doc Link 4050495 Disease Relevance 0.62 Pain Relevance 0.13
The authors review the subject and comment on their experience with clonidine, an imidazoline derivative marketed as an antihypertensive agent, and suggest that REM suppression is not always necessary for narcoleptics to improve.
Negative_regulation (suppression) of REM associated with clonidine
2) Confidence 0.38 Published 1985 Journal Acta Psiquiatr Psicol Am Lat Section Abstract Doc Link 4050495 Disease Relevance 0.52 Pain Relevance 0.14
A mean decrease of 66.9% in the GES was obtained at the end of the treatment period, which implies a good or excellent result in the prophylaxis of migraine attacks in 69.5% of the patients.
Negative_regulation (decrease) of GES associated with migraine
3) Confidence 0.37 Published 1988 Journal Cephalalgia Section Abstract Doc Link 3052850 Disease Relevance 0.39 Pain Relevance 0.39
In contrast, medium-dose clonidine significantly decreased REM and increased NREM on drug nights compared to baseline nights in the entire night.
Negative_regulation (decreased) of REM associated with clonidine
4) Confidence 0.37 Published 2004 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 15009817 Disease Relevance 0 Pain Relevance 1.03
A decrease in the mean REM sleep episode duration and REM sleep percentage can be due to degeneration of the nucleus basalis of Meynert.
Negative_regulation (decrease) of REM in nucleus
5) Confidence 0.18 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.77 Pain Relevance 0.10
These authors suggested that, since serotonergic functions act to suppress REM sleep, reduced serotonergic function in schizophrenia could explain the association between suicidal behavior and REM time/activity observed by other authors.
Negative_regulation (suppress) of REM associated with suicidal behaviour and schizophrenia
6) Confidence 0.11 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1845151 Disease Relevance 1.55 Pain Relevance 0.03
A pattern of reduced REM latency means that REM occurs earlier in the nightly sleep cycle, and is a symptom of depression.
Negative_regulation (reduced) of REM associated with depression
7) Confidence 0.08 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.22 Pain Relevance 0.44
By comparison, alcohol induced sleep is unnatural in that suppression of REM and slow wave sleep leaves the individual unrested and unstable the next day.
Negative_regulation (suppression) of REM associated with alcohol
8) Confidence 0.06 Published 2004 Journal Harm Reduct J Section Body Doc Link PMC419978 Disease Relevance 0.39 Pain Relevance 0.28
They reported a significant increase in stage 2 sleep (%) during the LP, no change in SWS, and failed to replicate the significant decrease in REM sleep (%) generally reported during this phase [54].
Negative_regulation (decrease) of REM
9) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
Comparing the sleep of healthy women at the mid-FP and mid-LP, one study found no significant differences between any sleep parameter (including SE, SOL, REM sleep and SWS) [43], whereas another report detailed significantly decreased REM sleep (%) and significantly increased SWS (%) at the mid-LP compared to the mid-FP [53].
Negative_regulation (decreased) of REM
10) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.23 Pain Relevance 0.18
The most consistently observed menstrual cycle-related changes in the sleep profile of healthy women are a reduction of REM sleep [49, 51–53, 56], with a maintenance of homeostatic sleep mechanisms throughout the cycle [90], and a robust variation of SFA across the menstrual cycle [48, 49, 55], which increases in association with progesterone during the LP.
Negative_regulation (reduction) of REM
11) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.57 Pain Relevance 0.08
Similarly, women with PMS/PMDD have also shown decreases in REM sleep [52, 56] and increases in SFA [55] during the LP compared to the FP.
Negative_regulation (decreases) of REM associated with dismenorea and premenstrual syndrome
12) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.52 Pain Relevance 0.10
The results from eighteen healthy controls studied by Parry et al. at the mid-FP and late-LP as part of a larger study of sleep in PMDD found increases in ROL (min) and stage 1 sleep (%), and decreased REM sleep (min) and stage 3 (min and %) during the late-LP compared to the mid-FP [52].
Negative_regulation (decreased) of REM in stage 3 associated with premenstrual syndrome
13) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.26 Pain Relevance 0.16
Specifically, progesterone, as well as its neuroactive metabolites, can affect sleep architecture, as was illustrated by the findings that exogenous progesterone [69] or megestrol acetate, a progesterone-receptor agonist [70], reduced REM sleep in male participants.
Negative_regulation (reduced) of REM associated with agonist
14) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0.05
The most common sleep findings across the menstrual cycle include decreases in REM sleep, increases in stage 2 sleep and SFA, and no changes in sleep propensity and quality (SOL and SE, resp.) during the LP compared to the FP.
Negative_regulation (decreases) of REM
15) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
The finding of reduced REM sleep during the LP, when nocturnal body temperature is significantly elevated compared to the FP, is therefore interesting.
Negative_regulation (reduced) of REM in body
16) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0.08
Other comparisons of PMS/PMDD women and healthy control women showed patients to have increased stage 2 sleep, decreased REM sleep, or decreased SWS regardless of menstrual phase (Table 2).
Negative_regulation (decreased) of REM associated with dismenorea and premenstrual syndrome
17) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.12 Pain Relevance 0.44
More recently, a study including healthy women and those with PMS found decreased SWS (%) and REM sleep (%) as well as increased stage 2 (%) during the LP in both groups [56].
Negative_regulation (decreased) of REM associated with dismenorea
18) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.84 Pain Relevance 0.52
Likewise, exogenous progesterone in rats reduced REM sleep while lengthening ROL [71].
Negative_regulation (reduced) of REM
19) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0.05
First, similar reductions in REM were seen in all three hypnotic-treated groups, yet only TRA significantly impaired plasticity in V1.
Negative_regulation (reductions) of REM
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699540 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox