INT346244

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 7.42
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX2) nucleus (RUNX2) DNA binding (RUNX2)
Anatomy Link Frequency
chondrocytes 5
cartilage 1
RUNX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1030 99.60 Very High Very High Very High
Inflammation 160 97.36 Very High Very High Very High
cytokine 80 83.88 Quite High
Inflammatory stimuli 10 82.48 Quite High
Arthritis 80 73.76 Quite High
rheumatoid arthritis 40 53.88 Quite High
Pain 20 51.04 Quite High
metalloproteinase 60 26.32 Quite Low
Immobilon 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 1040 99.60 Very High Very High Very High
Disease 50 97.72 Very High Very High Very High
INFLAMMATION 140 97.36 Very High Very High Very High
Arthritis 90 89.96 High High
Targeted Disruption 30 85.88 High High
Experimental Arthritis 10 65.64 Quite High
Rheumatoid Arthritis 40 53.88 Quite High
Pain 10 51.04 Quite High
Apoptosis 10 33.76 Quite Low
Stress 10 26.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced activation of transcription factor RUNX-2 in human OA chondrocytes
Positive_regulation (activation) of RUNX-2 in chondrocytes associated with osteoarthritis
1) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.75 Pain Relevance 0.37
for 30 minutes as described above and the activation of RUNX-2 was analyzed by Western immunoblotting (Figure 5a).
Positive_regulation (activation) of RUNX-2
2) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.70 Pain Relevance 0.35
significantly enhanced the DNA binding activity of RUNX-2 compared to controls (Figure 5b; P < 0.001).
Positive_regulation (enhanced) of RUNX-2
3) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.67 Pain Relevance 0.33
It is well documented that activation of the runt-related transcription factor RUNX-2 is mediated by activated p38-MAPK as inhibition of p38-MAPK abrogates its activity and the expression of cartilage degrading enzymes in chondrocytes [16].
Positive_regulation (activation) of runt-related transcription factor RUNX-2 in cartilage
4) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.49 Pain Relevance 0.27
It is well established that in chondrocytes activation of RUNX-2 is mediated by activated p38-MAPK [16].
Positive_regulation (activation) of RUNX-2 in chondrocytes
5) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.86 Pain Relevance 0.33
-induced activation of RUNX-2 and this correlates with the inhibition of p38-MAPK activation.
Positive_regulation (activation) of RUNX-2
6) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.79 Pain Relevance 0.39
-induced activation of RUNX-2 in human OA chondrocytes.
Positive_regulation (activation) of RUNX-2 in chondrocytes associated with osteoarthritis
7) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.01 Pain Relevance 0.43
-induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor RUNX-2 in primary human OA chondrocytes.


Positive_regulation (activation) of RUNX-2 in chondrocytes associated with osteoarthritis
8) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.59 Pain Relevance 0.30
-induced DNA binding activity of the transcription factor RUNX-2 we used a sandwich ELISA assay kit.
Positive_regulation (induced) of RUNX-2
9) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.32
induced activation and DNA binding activity of the transcription factor RUNX2 in human OA chondrocytes.
Positive_regulation (activation) of RUNX2 in chondrocytes associated with osteoarthritis
10) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.93 Pain Relevance 0.44

General Comments

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