INT346246

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 6
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 309 100.00 Very High Very High Very High
imagery 3 39.80 Quite Low
Immobilon 3 20.12 Low Low
Inflammation 48 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
Arthritis 24 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 312 100.00 Very High Very High Very High
Targeted Disruption 9 95.80 Very High Very High Very High
INFLAMMATION 42 5.00 Very Low Very Low Very Low
Arthritis 27 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Hypertrophy 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of human OA chondrocytes with MKK3 or MKK6-specific siRNAs knocked down the expression of target proteins and inhibited the IL-1?
Positive_regulation (Transfection) of Gene_expression (Transfection) of MKK6 in chondrocytes associated with osteoarthritis
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.08 Pain Relevance 0.45
Expression and activation of MKK3 and MKK6 in human OA chondrocytes
Positive_regulation (activation) of Gene_expression (Expression) of MKK6 in chondrocytes associated with osteoarthritis
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.43 Pain Relevance 0.22
Human OA chondrocytes were transfected with human MKK3 or MKK6-specific siRNAs using On-Target SMART Pools (# L-00350900, L-00396700, Dharmacon RNA Technologies, Lafayette, CO, USA).
Positive_regulation (transfected) of Gene_expression (transfected) of MKK6 in chondrocytes associated with osteoarthritis
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.22 Pain Relevance 0.11

General Comments

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