INT346257

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 9.05
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX2) nucleus (RUNX2) DNA binding (RUNX2)
Anatomy Link Frequency
chondrocytes 5
RUNX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1545 99.60 Very High Very High Very High
Arthritis 120 74.56 Quite High
Inflammation 240 74.16 Quite High
metalloproteinase 90 60.60 Quite High
Pain 30 48.24 Quite Low
rheumatoid arthritis 60 45.92 Quite Low
Inflammatory stimuli 15 41.60 Quite Low
cytokine 120 5.16 Low Low
Immobilon 15 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 1560 99.60 Very High Very High Very High
Arthritis 135 74.56 Quite High
INFLAMMATION 210 71.88 Quite High
Disease 75 70.72 Quite High
Frailty 15 66.16 Quite High
Pain 15 48.24 Quite Low
Rheumatoid Arthritis 60 45.92 Quite Low
Hypertrophy 15 29.20 Quite Low
Arthralgia 15 14.64 Low Low
Targeted Disruption 45 7.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation and DNA binding activity of RUNX-2 in human OA chondrocytes pretreated with PE (2 h) and then stimulated with IL-1?
RUNX-2 Binding (activity) of in chondrocytes associated with osteoarthritis
1) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.37 Pain Relevance 0.19
Activation and DNA binding activity of RUNX-2 in human OA chondrocytes pretreated with PE (2 h) and then stimulated with IL-1?
RUNX-2 Binding (binding) of in chondrocytes associated with osteoarthritis
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.37 Pain Relevance 0.19
significantly enhanced the DNA binding activity of RUNX-2 compared to controls (Figure 5b; P < 0.001).
RUNX-2 Binding (activity) of
3) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.66 Pain Relevance 0.33
-induced DNA binding activity of the transcription factor RUNX-2 we used a sandwich ELISA assay kit.
RUNX-2 Binding (binding) of
4) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.32
-induced increase in the DNA binding activity of RUNX-2 was inhibited significantly by PE in a dose-dependent manner (12.5 to 100 ?
RUNX-2 Binding (binding) of
5) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.65 Pain Relevance 0.33
-induced DNA binding activity of RUNX-2 was also inhibited by PE in primary human OA chondrocytes and correlated with the inhibition of p38?
RUNX-2 Binding (activity) of in chondrocytes associated with osteoarthritis
6) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.84 Pain Relevance 0.46
-induced increase in the DNA binding activity of RUNX-2 was inhibited significantly by PE in a dose-dependent manner (12.5 to 100 ?
RUNX-2 Binding (activity) of
7) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.65 Pain Relevance 0.32
-induced DNA binding activity of RUNX-2 was also inhibited by PE in primary human OA chondrocytes and correlated with the inhibition of p38?
RUNX-2 Binding (binding) of in chondrocytes associated with osteoarthritis
8) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.85 Pain Relevance 0.46
-induced DNA binding activity of RUNX-2 in human OA chondrocytes.


RUNX-2 Binding (binding) of in chondrocytes associated with osteoarthritis
9) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.57 Pain Relevance 0.29
DNA binding activity of RUNX-2 was determined using a highly sensitive and specific ELISA.
RUNX-2 Binding (activity) of
10) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.34
DNA binding activity of RUNX-2 was determined using a highly sensitive and specific ELISA.
RUNX-2 Binding (binding) of
11) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.35
RUNX-2 DNA binding activity assay
RUNX-2 Binding (assay) of
12) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.37 Pain Relevance 0.19
RUNX-2 DNA binding activity assay
RUNX-2 Binding (binding) of
13) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.37 Pain Relevance 0.18
-MAPK isoform and the activation and DNA binding activity of the transcription factor RUNX-2.
RUNX-2 Binding (activity) of
14) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.34
-MAPK isoform and the activation and DNA binding activity of the transcription factor RUNX-2.
RUNX-2 Binding (binding) of
15) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.37

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