INT346259

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.29

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency joint 2 TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 8 97.88 Inflammation 16 74.40 cytokine 8 73.44 Pain 2 73.04 Osteoarthritis 103 57.44 metalloproteinase 6 48.32 rheumatoid arthritis 4 43.44 Inflammatory stimuli 1 5.00 Immobilon 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Arthritis 9 97.88 Targeted Disruption 3 75.44 INFLAMMATION 14 74.40 Pain 1 73.04 Disease 5 70.80 Osteoarthritis 104 57.44 Experimental Arthritis 1 55.20 Rheumatoid Arthritis 4 43.44 Apoptosis 1 23.32 Hypertrophy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These and other studies [17] clearly show that inhibition of specific MAPKs or transcription factor may be an effective approach for the inhibition of joint destruction in arthritis.

Regulation (effective) of Negative_regulation (inhibition) of transcription factor in joint associated with arthritis

1) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.58 Pain Relevance 0.29

General Comments

This test has worked.