INT346302

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ELANE, Col2a1) cytoplasm (ELANE, Col2a1) extracellular space (Col2a1)
peptidase activity (ELANE) proteinaceous extracellular matrix (Col2a1)
Anatomy Link Frequency
chondrocyte 1
ELANE (Homo sapiens)
Col2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 37 90.76 High High
Inflammation 6 9.40 Low Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 90.96 High High
Osteoarthritis 39 90.76 High High
Osteoporosis 1 67.04 Quite High
Adhesions 24 51.44 Quite High
INFLAMMATION 9 9.40 Low Low
Aging 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When seeded in HNE-treated Coll II, significant amendment of chondrocyte morphology, from the typical chondrocyte-like polygon shape to rounded, semi-detached cells, was observed; mainly when Col II was modified by HNE at a 1:200 MR (Col II:HNE).
HNE Regulation (modified) of Col II in chondrocyte
1) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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