INT346305

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ELANE, Col2a1) cytoplasm (ELANE, Col2a1) extracellular space (Col2a1)
peptidase activity (ELANE) proteinaceous extracellular matrix (Col2a1)
Anatomy Link Frequency
chondrocyte 1
ELANE (Homo sapiens)
Col2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 111 95.80 Very High Very High Very High
Inflammation 18 74.96 Quite High
metalloproteinase 15 47.64 Quite Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 3 99.52 Very High Very High Very High
Adhesions 72 98.84 Very High Very High Very High
Osteoarthritis 117 95.80 Very High Very High Very High
Death 21 76.60 Quite High
INFLAMMATION 27 74.96 Quite High
Aging 9 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our novel findings indicate that HNE-binding to Col II results in multiple abnormalities of chondrocyte phenotype and function, suggesting its contribution in osteoarthritis development.
HNE Binding (binding) of Col II in chondrocyte associated with reprotox - general 3 and osteoarthritis
1) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991038 Disease Relevance 0.63 Pain Relevance 0.09
HNE-binding to Col II modulates the expression of adhesion molecules (ICAM-1 and ?
HNE Binding (binding) of Col II associated with adhesions
2) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.27 Pain Relevance 0.04
However, Col II modification with HNE at a 1:200 MR significantly decreased the Feret's diameter of cell compared to the control.
HNE Binding (modification) of Col II
3) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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