INT346376

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.00
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tesc) nucleus (Tesc) cytoplasm (Tesc)
Anatomy Link Frequency
neurons 2
Spores 1
inhibitory interneurons 1
Tesc (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 16 87.52 High High
Spinal cord 184 82.24 Quite High
Central nervous system 24 28.16 Quite Low
tetrodotoxin 56 5.00 Very Low Very Low Very Low
Action potential 20 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 4 99.80 Very High Very High Very High
Injury 8 98.96 Very High Very High Very High
Anaerobic Bacterial Infections 88 96.36 Very High Very High Very High
Disease 24 96.04 Very High Very High Very High
Myocardial Infarction 4 91.52 High High
Paralysis 28 84.20 Quite High
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Infection 16 5.00 Very Low Very Low Very Low
Poisoning 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another issue raised by the results presented here is the question of how TeNT is released from its receptor in MNs such that it can bind to SV2 on inhibitory interneurons following transcytosis.
Localization (released) of TeNT in inhibitory interneurons
1) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.14 Pain Relevance 0.07
The loss of PSGs might dramatically reduce the affinity of TeNT for the peripheral receptor, relative to SV2, so TeNT can be released from the MN and target inhibitory neurons after transcytosis.
Localization (released) of TeNT in neurons
2) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.03
TeNT then undergoes transcytosis by being released from the MNs such that it enters upstream inhibitory neurons to cleave SNAREs and inhibit transmitter release [18], [19].
Localization (released) of TeNT in neurons
3) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.13 Pain Relevance 0.07
Spores enter via deep wounds where they germinate in the anaerobic environment, releasing TeNT via autolysis [1].
Localization (releasing) of TeNT in Spores associated with autolysis and injury
4) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.73 Pain Relevance 0.04

General Comments

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