INT346381

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sv2a) transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a)
transmembrane transport (Sv2a) cytoplasm (Sv2a)
Anatomy Link Frequency
neurons 2
spinal cord 1
Sv2a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 138 98.76 Very High Very High Very High
Action potential 15 88.68 High High
Central nervous system 18 49.48 Quite Low
Neurotransmitter 12 41.52 Quite Low
tetrodotoxin 42 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 66 94.08 High High
Disease 18 89.44 High High
Targeted Disruption 18 79.52 Quite High
Trismus 3 62.64 Quite High
Paralysis 21 43.76 Quite Low
Poisoning 6 15.12 Low Low
Infection 12 10.16 Low Low
Injury 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that SV2B expression is largely localized to excitatory terminals while SV2A is preferentially localized to inhibitory neurons in both cortical cultures and spinal cord slices; this differential distribution was more striking with cortical neurons.
Localization (localized) of SV2A in spinal cord associated with spinal cord
1) Confidence 0.69 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.12
We found that among cortical neurons, SV2A is largely colocalized with inhibitory neurons, while SV2B is colocalized with excitatory neurons (Figure 6C–D).
Localization (colocalized) of SV2A in neurons
2) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.07 Pain Relevance 0.27
Further examination of the distribution of SV2A and SV2B in both spinal cord and cortical neurons revealed that SV2B is to a large extent localized to excitatory terminals, while SV2A is localized to inhibitory terminals.
Localization (localized) of SV2A in neurons associated with spinal cord
3) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2991259 Disease Relevance 1.04 Pain Relevance 0.22

General Comments

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