INT346382

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.17

transport (Sv2a) transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a) transmembrane transport (Sv2a) cytoplasm (Sv2a)

Anatomy Link Frequency neurons 1 Sv2a (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 92 92.48 Central nervous system 12 64.60 Neurotransmitter 8 35.64 tetrodotoxin 28 5.00 Action potential 10 5.00 antagonist 6 5.00 sodium channel 2 5.00 nMDA receptor antagonist 2 5.00 gABA 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Anaerobic Bacterial Infections 44 50.00 Infection 8 48.88 Paralysis 14 32.32 Injury 4 7.28 Targeted Disruption 12 5.00 Disease 12 5.00 Poisoning 4 5.00 Toxicity 2 5.00 Death 2 5.00 Autolysis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To determine, definitively, whether TeNT relies on SV2 to bind and enter neurons, we took advantage of SV2A/B KO mice [51], [52].

Spec (whether) Regulation (relies) of SV2 in neurons

1) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.17

Therefore, once TeNT reaches a MN, it targets the peripheral receptor rather than SV2.

Regulation (targets) of SV2

2) Confidence 0.22 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0

General Comments

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