INT346382

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sv2a) transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a)
transmembrane transport (Sv2a) cytoplasm (Sv2a)
Anatomy Link Frequency
neurons 1
Sv2a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 92 92.48 High High
Central nervous system 12 64.60 Quite High
Neurotransmitter 8 35.64 Quite Low
tetrodotoxin 28 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 44 50.00 Quite Low
Infection 8 48.88 Quite Low
Paralysis 14 32.32 Quite Low
Injury 4 7.28 Low Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Poisoning 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Autolysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine, definitively, whether TeNT relies on SV2 to bind and enter neurons, we took advantage of SV2A/B KO mice [51], [52].
Spec (whether) Regulation (relies) of SV2 in neurons
1) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.17
Therefore, once TeNT reaches a MN, it targets the peripheral receptor rather than SV2.
Regulation (targets) of SV2
2) Confidence 0.22 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0

General Comments

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