INT346389

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sv2a) transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a)
transmembrane transport (Sv2a) cytoplasm (Sv2a)
Anatomy Link Frequency
neurons 1
spinal cord neurons 1
Sv2a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 184 100.00 Very High Very High Very High
tetrodotoxin 56 81.68 Quite High
gABA 4 67.28 Quite High
Central nervous system 24 59.32 Quite High
Glutamate 4 59.32 Quite High
Action potential 20 10.08 Low Low
Neurotransmitter 16 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 100.00 Very High Very High Very High
Poisoning 8 63.24 Quite High
Infection 16 59.44 Quite High
Anaerobic Bacterial Infections 88 50.00 Quite Low
Paralysis 28 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Autolysis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that loss of SV2 does not affect normal uptake of toxins that target SVs and furthermore, in contrast to previous suggestions, SV2A/B is not required for normal uptake of BoNT/F [50], [58].


Negative_regulation (loss) of SV2
1) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.16 Pain Relevance 0.08
However, it remains possible that loss of SV2 might prevent the proper expression or targeting of yet-to-be identified protein receptors for TeNT.
Negative_regulation (loss) of SV2
2) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.03
We first cultured spinal cord neurons that lacked SV2A/B and monitored binding of a receptor-binding fragment of TeNT; WT neurons served as controls.
Negative_regulation (lacked) of SV2A/B in neurons associated with spinal cord
3) Confidence 0.40 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.06 Pain Relevance 0.17
SV2 knockout spinal cord neurons were prepared from E12.5?
Negative_regulation (prepared) of SV2 in spinal cord neurons associated with targeted disruption and spinal cord
4) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.19 Pain Relevance 0.34

General Comments

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