INT34644

Context Info Confidence 0.47 First Reported 1988 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 19 Total Number 20 Disease Relevance 9.41 Pain Relevance 2.20

extracellular region (HLA-C) plasma membrane (HLA-C)

Anatomy Link Frequency leukocyte 2 articular 1 groove 1 HLA-C (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 123 99.32 spondylitis 30 99.20 psoriasis 62 99.16 spinal inflammation 32 99.12 endometriosis 12 88.64 Inflammation 25 84.24 cINOD 9 76.64 cytokine 18 70.36 Inflammatory response 2 51.12 tolerance 3 8.80

Disease Link Frequency Relevance Heat Disease 541 100.00 Seronegative Spondarthritis 106 99.60 Aging 18 99.52 Psoriasis 64 99.16 Low Back Pain 54 99.12 Adverse Drug Reaction 128 97.40 Cognitive Disorder 27 96.92 Arthritis 35 95.92 Disorder Of Lipid Metabolism 27 95.76 Syndrome 55 93.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Only a weak tendency towards an association with HLA-Cw15 overall remained after correction (p = 0.1).

HLA-Cw15 Binding (association) of

1) Confidence 0.47 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.14 Pain Relevance 0

Apart from the associations with HLA-B7 and HLA-Cw*0702 (see below), there was one other apparently significant association, i.e. with HLA-Cw15, before correction for multiple testing.

HLA-Cw Binding (associations) of

2) Confidence 0.47 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.10 Pain Relevance 0

The clinical features of 27 cases, which the authors classified as probable NSD, are as follows: 1) both sexes are almost evenly affected; 2) people of ages 30 to 70 years are affected; 3) encephalitis and meningitis are common neurologic manifestations; 4) any region of the CNS can be involved, resulting in a variety of neurologic symptoms; 5) there is a strong human leukocyte antigen-Cw1 association; 6) systemic corticosteroids are highly effective for most of the neurologic manifestations, although recurrences are not infrequent.

antigen-Cw1 Binding (association) of in leukocyte

3) Confidence 0.41 Published 2005 Journal Neurology Section Body Doc Link 15911805 Disease Relevance 0.07 Pain Relevance 0

Particular attention is focused on the genetic epidemiology of AS, especially the evidence supporting causal association of disease with the class I histocompatibility antigen HLA-B27.

I histocompatibility antigen HLA-B27 Binding (association) of associated with spinal inflammation and disease

4) Confidence 0.41 Published 1988 Journal J Rheumatol Suppl Section Abstract Doc Link 3057207 Disease Relevance 1.08 Pain Relevance 0.62

Possible interactions of HLA-B7 and HLA-Cw*0702 with other factors

HLA-Cw Binding (interactions) of

5) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.24 Pain Relevance 0

We suggest that the only results meriting further scrutiny are those for HLA-B7 and HLA-Cw*0702 and possibly the potentially reduced risk associated with HLA-Cw15.

HLA-Cw15 Binding (associated) of

6) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.37 Pain Relevance 0

Apart from the associations with HLA-B7 and HLA-Cw*0702 (see below), there was one other apparently significant association, i.e. with HLA-Cw15, before correction for multiple testing.

HLA-Cw15 Binding (association) of

7) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.09 Pain Relevance 0

Neither HLA-B7 nor HLA-Cw*0702 was associated with onset age of AD (data not shown).

HLA-Cw Binding (associated) of associated with disease

8) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.38 Pain Relevance 0

Our own previous study [9], with 55 cases of AD and 73 controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA), suggested an association with AD of two alleles in linkage disequilibrium with each other, HLA-B7 and HLA-Cw*0702, especially in people without the ?

HLA-Cw Binding (association) of associated with aging and disease

9) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 1.21 Pain Relevance 0.18

We aimed to replicate the association with HLA-B7 and HLA-Cw*0702 and to examine other alleles at those loci.

HLA-Cw Spec (examine) Binding (association) of

10) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.86 Pain Relevance 0

A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study.

HLA-Cw Binding (association) of

11) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1764414 Disease Relevance 0.58 Pain Relevance 0

Of the 5 identified associations between HLA-E and HLA-Cw/B, the most significant were (E*0101, Cw*0701, B*0801) and (E*010302, Cw*0702, B*0702).

HLA-Cw Binding (associations) of

12) Confidence 0.33 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

The clinical features of 27 cases, which the authors classified as probable NSD, are as follows: 1) both sexes are almost evenly affected; 2) people of ages 30 to 70 years are affected; 3) encephalitis and meningitis are common neurologic manifestations; 4) any region of the CNS can be involved, resulting in a variety of neurologic symptoms; 5) there is a strong human leukocyte antigen-Cw1 association; 6) systemic corticosteroids are highly effective for most of the neurologic manifestations, although recurrences are not infrequent.

antigen-Cw1 Binding (association) of in leukocyte

13) Confidence 0.32 Published 2005 Journal Neurology Section Body Doc Link 15911805 Disease Relevance 0.07 Pain Relevance 0

In the case of HLA-Cw*4, all sulfonamides bind to the antigen presentation groove.

HLA-Cw Binding (bind) of in groove

14) Confidence 0.30 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.19 Pain Relevance 0

We found an association with C2 homozygosity in ankylosing spondylitis, which seems to be concordant with results in Chinese, where an association of the HLA-Cw*02 allele (a member of the C2 group) with this disease was described [9].

HLA-Cw Binding (association) of associated with spinal inflammation and disease

15) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.99 Pain Relevance 0.24

Table S4 showed significant differences between case and control interactions with HLA-Cw*4 either in docking scores or in Z-scores.

HLA-Cw Binding (interactions) of

16) Confidence 0.29 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.60 Pain Relevance 0.03

This is the first study to show a significant association between HLA-Cw*0702 and psoriatic spondylitis, and this relationship might have an additive effect with regard to the presence of HLA-B27.

HLA-Cw Binding (association) of associated with seronegative spondarthritis and spondylitis

17) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794531 Disease Relevance 1.00 Pain Relevance 0.45

We performed HLA-C locus PCR-SSOP typing in both psoriasis and PsA patients and confirmed the known association between HLA-Cw*0602 and both entities; however, when articular subgroup comparisons were made, this allele was equally distributed between them, supporting the notion that genetic susceptibility to PsA resides in another gene.

HLA-Cw Binding (association) of in articular associated with psoriasis, genetic predisposition to disease and arthritis

18) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794531 Disease Relevance 1.47 Pain Relevance 0.69

Many significant HLA-Cw/B associations were found within Panel 2, as expected due to the physical proximity of HLA-Cw and -B (85 kb).

HLA-Cw Binding (associations) of

19) Confidence 0.27 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

A linkage to other HLA alleles observed here, even in our HLA-B27-negative USpA patients, strongly suggests that USpA in general is a genetic disease.

HLA Binding (linkage) of

20) Confidence 0.16 Published 2007 Journal Semin. Arthritis Rheum. Section Body Doc Link 17604825 Disease Relevance 0 Pain Relevance 0

General Comments

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