INT346479

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.30
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDX58) helicase activity (DDX58) cytoplasm (DDX58)
Anatomy Link Frequency
dendritic cells 2
DDX58 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 100 98.80 Very High Very High Very High
Inflammation 75 97.52 Very High Very High Very High
adenocard 5 76.92 Quite High
chemokine 10 67.44 Quite High
fibrosis 35 65.72 Quite High
Inflammatory response 5 38.28 Quite Low
agonist 5 35.92 Quite Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 99.04 Very High Very High Very High
INFLAMMATION 85 97.52 Very High Very High Very High
Hepatitis C Virus Infection 360 95.08 Very High Very High Very High
Disorder Of Lipid Metabolism 10 73.20 Quite High
Hepatocellular Cancer 380 67.48 Quite High
Cirrhosis 140 65.72 Quite High
Hepatitis B Virus Infection 50 62.72 Quite High
Liver Cancer 55 56.72 Quite High
Hepatitis 50 38.72 Quite Low
Cancer 85 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One is mediated by retinoic acid inducible gene-I (RIG-I) retinoic acid/MDA5 while MyD88 (myeloid differentiation primary response gene 88) activates the other.
Positive_regulation (inducible) of gene-I
1) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.12 Pain Relevance 0.03
One is mediated by retinoic acid inducible gene-I (RIG-I) retinoic acid/MDA5 while MyD88 (myeloid differentiation primary response gene 88) activates the other.
Positive_regulation (inducible) of RIG-I
2) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.12 Pain Relevance 0.03
RIG-1 is activated by the binding of viral RNA, which enables RIG-1 to bind to IFN promoter stimulator 1(IPS-1) and trigger a signaling cascade that results in IFN transcription.
Positive_regulation (activated) of RIG-1
3) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.54 Pain Relevance 0.16
In addition, dendritic cells (DC) sense virus infection via toll-like receptors (TLR) or retinoic acid inducible gene-I (RIG-I), resulting in the secretion of type-I interferons (IFN) and inflammatory cytokines.
Positive_regulation (inducible) of gene-I in dendritic cells associated with inflammation, infection and cytokine
4) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.25 Pain Relevance 0.10
In addition, dendritic cells (DC) sense virus infection via toll-like receptors (TLR) or retinoic acid inducible gene-I (RIG-I), resulting in the secretion of type-I interferons (IFN) and inflammatory cytokines.
Positive_regulation (inducible) of RIG-I in dendritic cells associated with inflammation, infection and cytokine
5) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.25 Pain Relevance 0.10

General Comments

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