INT346492

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MAVS) mitochondrion (MAVS) signal transducer activity (MAVS)
MAVS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 91.64 High High
adenocard 3 69.76 Quite High
chemokine 6 60.28 Quite High
Inflammation 45 50.00 Quite Low
fibrosis 21 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 216 100.00 Very High Very High Very High
Hepatocellular Cancer 228 50.00 Quite Low
INFLAMMATION 51 50.00 Quite Low
Infection 60 31.76 Quite Low
Cirrhosis 84 5.00 Very Low Very Low Very Low
Cancer 51 5.00 Very Low Very Low Very Low
Liver Cancer 33 5.00 Very Low Very Low Very Low
Hepatitis 30 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 30 5.00 Very Low Very Low Very Low
Fibrosis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IPS-1 is normally localized to the membranes of mitochondria but the HCV NS3-4a protease cleaves IPS-1, which causes it to delocalize from the mitochondrial membrane and prevents RIG-1 signaling.
Protein_catabolism (cleaves) of IPS-1 associated with hepatitis c virus infection
1) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.54 Pain Relevance 0.13
IPS-1 is normally localized to the membranes of mitochondria but the HCV NS3-4a protease cleaves IPS-1, which causes it to delocalize from the mitochondrial membrane and prevents RIG-1 signaling.
Protein_catabolism (cleaves) of IPS-1 associated with hepatitis c virus infection
2) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.56 Pain Relevance 0.14
By cleaving IPS-1 and inactivating TRIF, HCV disrupts the ability of a cell to detect its presence, as a consequence, IFN production is diminished and host defenses are impaired [23].
Protein_catabolism (cleaving) of IPS-1 associated with hepatitis c virus infection
3) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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