INT346500

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.13

cytoplasm (TLR3, Nfkb1) signal transduction (TLR3, Nfkb1) endosome (TLR3) mitochondrion (Nfkb1) endoplasmic reticulum (TLR3) intracellular (TLR3)

TLR3 (Homo sapiens) Nfkb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 20 96.08 chemokine 2 95.28 adenocard 1 76.24 Inflammation 15 50.00 fibrosis 7 28.72 COX-2 inhibitor 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Bile 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 72 90.64 Infection 20 55.20 Hepatocellular Cancer 76 50.00 INFLAMMATION 17 50.00 Disorder Of Lipid Metabolism 2 36.20 Cirrhosis 28 28.72 Hepatitis B Virus Infection 10 25.72 Liver Cancer 11 19.72 Cancer 17 5.00 Hepatitis 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MyD88 is a universal adaptor protein being used by other TLRs (except TLR-3) to activate the transcription factor NF-kB.

TLR-3 Positive_regulation (activate) of NF-kB

1) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

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