INT346527

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.11
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11)
plasma membrane (PTH2R) DNA binding (TFIP11) cytoplasm (TFIP11)
Anatomy Link Frequency
parathyroid 2
TM3 1
PTH2R (Homo sapiens)
TFIP11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 8 89.28 High High
antagonist 16 87.04 High High
agonist 8 76.08 Quite High
adenocard 8 70.96 Quite High
Neuropathic pain 32 57.60 Quite High
Pain 16 53.28 Quite High
Sciatic nerve 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 32 57.60 Quite High
Pain 16 53.28 Quite High
Targeted Disruption 8 21.76 Low Low
Nociception 16 5.00 Very Low Very Low Very Low
Stress 16 5.00 Very Low Very Low Very Low
Nervous System Injury 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.
PTH2R Binding (binds) of TIP39
1) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11
We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex.
PTH2R Binding (interactions) of TIP39 in parathyroid
2) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
In this work, we present a hypothesis of how TIP39 could bind to PTH2R and how the receptor may discriminate among the related peptides TIP39, PTH and PTHrP.
PTH2R Binding (bind) of TIP39
3) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.11 Pain Relevance 0.15
Positions in PTH2R which have been shown to be directly involved in the discrimination between the PTH and PTHrP for PTH2R; Ile244 (interacts with Leu2 and Ala3 in TIP39 in the model of the complex) in TM3 and Cys397 (matched to Glu12 in TIP39) and Phe400 (in proximity of Ala5 and Ala8 in TIP39) in TM7 are in close contact with the placed ligand [38].
PTH2R Binding (interacts) of TIP39 in TM3
4) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.04
We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex.
parathyroid hormone-2 receptor Binding (interactions) of TIP39 in parathyroid
5) Confidence 0.18 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
Complexes with the hormones PTH and PTHrP and PTH2R were built by superimposing them upon the TIP39 - PTH2R complex, followed by energy minimisation.


PTH2R Binding (complex) of TIP39
6) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
Complexes with the hormones PTH and PTHrP and PTH2R were built by superimposing them upon the TIP39 - PTH2R complex, followed by energy minimisation.


PTH2R Binding (complex) of TIP39
7) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.
PTH2R Binding (binds) of TIP39
8) Confidence 0.16 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11

General Comments

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