INT346535

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11)
DNA binding (TFIP11) cytoplasm (TFIP11)
Anatomy Link Frequency
TM3 1
TFIP11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 12 93.12 High High
Sciatic nerve 3 65.92 Quite High
antagonist 6 61.20 Quite High
Kinase C 3 51.44 Quite High
Pain 6 32.96 Quite Low
adenocard 3 12.00 Low Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 99.00 Very High Very High Very High
Anxiety Disorder 3 96.20 Very High Very High Very High
Neuropathic Pain 12 93.12 High High
Targeted Disruption 3 84.88 Quite High
Nociception 6 81.76 Quite High
Nervous System Injury 3 65.28 Quite High
Pain 6 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study has shown that the TIP39 - PTH2R system is activated in response to acoustic stress [21].
Positive_regulation (activated) of TIP39 associated with stress
1) Confidence 0.39 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.75 Pain Relevance 0.25
Analysis of the 30 conformations deposited in the protein databank entry 1BZG [31] shows that 12 of the conformations have an irregular helical conformation in the loop region which leads us to the conclusion that the extended conformation shown to be bioactive for PTH might also be active for TIP39 and PTHrP.


Positive_regulation (active) of TIP39
2) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].
Positive_regulation (reach) of TIP39 in TM3
3) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

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