INT346535

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.75 Pain Relevance 0.25

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11) DNA binding (TFIP11) cytoplasm (TFIP11)

Anatomy Link Frequency TM3 1 TFIP11 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropathic pain 12 93.12 Sciatic nerve 3 65.92 antagonist 6 61.20 Kinase C 3 51.44 Pain 6 32.96 adenocard 3 12.00 agonist 3 5.00

Disease Link Frequency Relevance Heat Stress 6 99.00 Anxiety Disorder 3 96.20 Neuropathic Pain 12 93.12 Targeted Disruption 3 84.88 Nociception 6 81.76 Nervous System Injury 3 65.28 Pain 6 32.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another study has shown that the TIP39 - PTH2R system is activated in response to acoustic stress [21].

Positive_regulation (activated) of TIP39 associated with stress

1) Confidence 0.39 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.75 Pain Relevance 0.25

Analysis of the 30 conformations deposited in the protein databank entry 1BZG [31] shows that 12 of the conformations have an irregular helical conformation in the loop region which leads us to the conclusion that the extended conformation shown to be bioactive for PTH might also be active for TIP39 and PTHrP.

Positive_regulation (active) of TIP39

2) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].

Positive_regulation (reach) of TIP39 in TM3

3) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

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