INT346540

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0.15

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11) DNA binding (TFIP11) cytoplasm (TFIP11)

Anatomy Link Frequency cavity 1 TFIP11 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 6 94.44 Kinase C 3 81.36 adenocard 3 70.96 Neuropathic pain 12 5.00 Pain 6 5.00 agonist 3 5.00 Sciatic nerve 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 13.84 Neuropathic Pain 12 5.00 Pain 6 5.00 Nociception 6 5.00 Stress 6 5.00 Nervous System Injury 3 5.00 Anxiety Disorder 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In Figure 3A, one can see that the first residues of TIP39 bind in a hydrophobic site in the central cavity.

TIP39 Binding (bind) of in cavity

1) Confidence 0.31 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.05

TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.

TIP39 Binding (binds) of

2) Confidence 0.23 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11

As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.

TIP39 Binding (interacts) of

3) Confidence 0.20 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.