INT346540

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (TFIP11) nucleus (TFIP11) intracellular (TFIP11)
DNA binding (TFIP11) cytoplasm (TFIP11)
Anatomy Link Frequency
cavity 1
TFIP11 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 94.44 High High
Kinase C 3 81.36 Quite High
adenocard 3 70.96 Quite High
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 13.84 Low Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Figure 3A, one can see that the first residues of TIP39 bind in a hydrophobic site in the central cavity.
TIP39 Binding (bind) of in cavity
1) Confidence 0.31 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.05
TIP39 binds to both receptors, but to PTH2R a hundredfold stronger than to PTH1R and only signal through PTH2R.
TIP39 Binding (binds) of
2) Confidence 0.23 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.11
As only TIP39 causes internalisation of the receptor and the primary difference being an aspartic acid in position 7 of TIP39 that interacts with histidine 396 in the receptor, versus isoleucine/histidine residues in the related hormones, this might be a trigger interaction for the events that cause internalisation.


TIP39 Binding (interacts) of
3) Confidence 0.20 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0

General Comments

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