INT346549

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.88
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTH2R) signal transducer activity (PTH2R)
Anatomy Link Frequency
parathyroid 3
TM3 1
PTH2R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 98.88 Very High Very High Very High
adenocard 7 94.68 High High
Neuropathic pain 28 93.12 High High
Sciatic nerve 7 91.84 High High
Pain 14 85.68 High High
Kinase C 7 48.24 Quite Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 28 93.12 High High
Nervous System Injury 7 92.12 High High
Nociception 14 88.40 High High
Pain 14 85.68 High High
Stress 14 75.52 Quite High
Anxiety Disorder 7 69.16 Quite High
Targeted Disruption 7 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 1A shows the alignment of PTH2R and the templates used in the modelling.
PTH2R Binding (alignment) of
1) Confidence 0.25 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].
PTH2R Binding (binding) of in TM3
2) Confidence 0.25 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
There is a possibility of using TIP39 as a tool to investigate the function of PTH2R in more detail by defining its interaction sites with PTH2R and it may also be possible to use it as a source of antagonistic peptides as the truncated TIP39(7 - 39) is for the PTH1R.
PTH2R Binding (sites) of
3) Confidence 0.25 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.88 Pain Relevance 0.39
1 receptor [2], the human A2A Adenosine receptor [3] and squid rhodopsin [4,5] coupled with the structures of extra-cellular domains (ECDs) of several class B hormone receptors [6-9], including the parathyroid hormone-1 receptor (PTH1R), makes it possible to begin a computational exploration of possible interactions of the parathyroid hormone-2 receptor (PTH2R) [10] and its natural ligand, the tuberoinfundibular peptide of 39 residues (TIP39) [11,12].
PTH2R Binding (interactions) of in parathyroid associated with adenocard
4) Confidence 0.24 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.05
1 receptor [2], the human A2A Adenosine receptor [3] and squid rhodopsin [4,5] coupled with the structures of extra-cellular domains (ECDs) of several class B hormone receptors [6-9], including the parathyroid hormone-1 receptor (PTH1R), makes it possible to begin a computational exploration of possible interactions of the parathyroid hormone-2 receptor (PTH2R) [10] and its natural ligand, the tuberoinfundibular peptide of 39 residues (TIP39) [11,12].
parathyroid hormone-2 receptor Binding (interactions) of in parathyroid associated with adenocard
5) Confidence 0.24 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.05
Model of the complex of Parathyroid hormone-2 receptor and Tuberoinfundibular peptide of 39 residues

Background

Parathyroid hormone-2 receptor Binding (complex) of in Parathyroid
6) Confidence 0.24 Published 2010 Journal BMC Res Notes Section Title Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The importance of the N-terminal part has been highlighted by the fact that deletion of the six first residues makes the remainder a potent antagonist of the PTH1R, while losing much of the strength of the binding to the PTH2R [14,44].
PTH2R Binding (binding) of associated with antagonist
7) Confidence 0.21 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.05

General Comments

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