INT346566

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Sh3gl3) endosome (Sh3gl3) cytoplasm (Sh3gl3)
Anatomy Link Frequency
urine 2
Sh3gl3 (Mus musculus)
Pain Link Frequency Relevance Heat
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
hypoalgesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 36 99.16 Very High Very High Very High
Gauchers Disease 14 96.36 Very High Very High Very High
Cerebrovascular Disease 4 73.04 Quite High
Nociception 6 65.44 Quite High
Disease 22 59.56 Quite High
Renal Failure 2 50.16 Quite High
Renal Insufficiency 2 43.24 Quite Low
Neuropathic Pain 6 43.20 Quite Low
Polyuria 2 36.56 Quite Low
Death 2 34.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that such an inhibitor (eliglustat tartrate, Genz-112638) was effective at lowering GL-3 accumulation in a mouse model of Fabry disease.
Negative_regulation (lowering) of Positive_regulation (accumulation) of GL-3 associated with fabry disease
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2991350 Disease Relevance 0.53 Pain Relevance 0
Figure 2C depicts the total GL-3 excreted over 24 h, showing that although SRT significantly decreased urine GL-3 (?
Negative_regulation (decreased) of Positive_regulation (urine) of GL-3 in urine
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.17 Pain Relevance 0

General Comments

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